1134-50-5

Basic information

• Product Name: 1-Phenyl-1H-pyrazole-4-carboxylic acid
• Synonyms: 1-phenyl-pyrazole-4-carboxylicaci;ASINEX-REAG BAS 16289592;1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID;AKOS PAO-0321;1-phenyl-1H-pyrazole-4-carboxylic acid(SALTDATA: FREE);1-phenyl-1H-pyrazol-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1-phenyl-;1-phenyl-4-pyrazolecarboxylic acid
• CAS NO: 1134-50-5
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18
• EINECS: 413-030-8
• Product Categories: Building Blocks;C10;Chemical Synthesis;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 1134-50-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 222-227℃
• Boiling Point: 379.6 °C at 760 mmHg
• Flash Point: 183.4 °C
• Appearance: Light yellow powder
• Density: 1.28g/cm³
• Vapor Pressure: 1.93E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 3.75±0.10(Predicted)
• CAS DataBase Reference: 1-Phenyl-1H-pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-1H-pyrazole-4-carboxylic acid(1134-50-5)
• EPA Substance Registry System: 1-Phenyl-1H-pyrazole-4-carboxylic acid(1134-50-5)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 1
• RTECS: UQ6436000
• HazardClass: IRRITANT
• Hazardous Substances Data: 1134-50-5(Hazardous Substances Data)

Usage

General Description

1-Phenyl-1H-pyrazole-4-carboxylic acid, also known as PP4CA, is a chemical compound with the formula C11H10N2O2. It belongs to the class of organic compounds known as phenylpyrazoles, which are aromatic compounds containing a benzene ring linked (either directly or indirectly) to a pyrazole ring. Pyrazole is a five-membered aromatic heterocycle, containing two nitrogen atoms, and three carbon atoms. This chemical has uses in scientific research, particularly in the field of chemistry. Its exact properties may vary based on its molecular structure, concentration, and other factors.

InChI:InChI=1/C10H8N2O2/c13-10(14)8-6-11-12(7-8)9-4-2-1-3-5-9/h1-7H,(H,13,14)/p-1

Upstream product

• 35715-71-0 1-phenyl-4-pyrazolylmethyl chloride 
• 709-04-6 1-phenyl-1H-pyrazole-4-carbonitrile 
• 885-94-9 ethyl 1-phenylpyrazole-4-carboxylate 
• 2600-63-7 3-(1-phenylpyrazol-4-yl)acrylaldehyde 
• 59-88-1 phenylhydrazine hydrochloride 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 7188-96-7 1-Phenylpyrazol-4-carbonsaeure-methylester 
• 100-63-0 phenylhydrazine 
• 1126-00-7 1-phenylpyrazole 
• 60441-21-6 1-Methyl-3-(phenyl-hydrazonomethyl)-pyridinium; iodide 
• 75594-89-7 1-phenyl-4-(3-methyliminopropenyl)pyrazole 
• 57023-37-7 3-[(E)-(2-phenylhydrazinylidene)methyl]pyridine 
• 61466-44-2 4-(2-hydroxybenzoyl)-1-phenylpyrazole 
• 154405-48-8 4-(2-hydroxybenzoyl)-1-phenylhydrazole oxime 

Downstream Products

• 70817-26-4 (1-phenyl-1H-pyrazol-4-yl)methanol 
• 1126-00-7 1-phenylpyrazole 
• 15719-64-9 methylammonium carbonate 
• 267641-97-4 1-Phenyl-1H-pyrazole-4-carbonyl chloride 
• 405548-29-0 tert-butyl (1-phenyl-1H-pyrazol-4-yl)carbamate 
• 1418024-57-3 1-phenyl-1H-pyrazole-4-carboxylic acid [7-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-3-ylmethyl]amide 
• 700372-23-2 N-{2-[(furan-2-ylmethyl)thio]ethyl}-1-phenyl-1H-pyrazole-4-carboxamide 
• 1188373-29-6 1-phenyl-1H-pyrazole-4-carboxylic acid {2-[4-(2-chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethyl}-amide 
• 101893-32-7 1,1'-phenyl-4,4'-dipyrazolylmethane 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone

Aims: This study investigates the anti-nociceptive and anti-inflammatory effects of new piperazine compound (LQFM182) as well as the toxicity acute in vitro. Main methods: To evaluate the anti-nociceptive activity, the acetic acid-induced abdominal writhing test, tail flick test and formalin-induced pain test were used. The anti-inflammatory activity was evaluated using the models of paw oedema and pleurisy induced by carrageenan and some inflammatory parameters were evaluated, including cell migration, myeloperoxidase enzyme activity and the levels of TNF-α and IL-1β cytokines in pleural exudate. The acute oral systemic toxicity of LQFM182 in mice was evaluated through the neutral red uptake (nru) assay. Key findings: LQFM182 (50, 100 or 200?mg/kg, p.o.) decreased the number of writhings induced by acetic acid in a dose-dependent manner, and an intermediate dose (100?mg/kg, p.o.) reduced the paw licking time of animals in the second phase of the formalin test. Furthermore, LQFM182 (100?mg/kg, p.o.) reduced oedema formation at all hours of the paw oedema induced by carrageenan test and in pleurisy test reduced cell migration from the reduction of polymorphonuclear cells, myeloperoxidase enzyme activity and the levels of pro-inflammatory cytokines IL-1β and TNF-α. Therefore, it was classified in GHS category 300?50??2000?mg/kg. Significance: Reduction of the TNF-α and IL-1β levels.

Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages

Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentati