1134-82-3

Basic information

• Product Name: 2-BENZYL-5-METHYL-2H-PYRAZOL-3-YLAMINE
• Synonyms: 1-BENZYL-3-METHYL-1H-PYRAZOL-5-AMINE;2-BENZYL-5-METHYL-2H-PYRAZOL-3-YLAMINE;AKOS B024965;ART-CHEM-BB B024965;CHEMBRDG-BB 4013080;TIMTEC-BB SBB004439;1-benzyl-3-methyl-1H-pyrazol-5-amine hydrochloride;Albb-006142
• CAS NO: 1134-82-3
• Molecular Formula: C₁₁H₁₃N₃
• Molecular Weight: 187.24
• Mol File: 1134-82-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 69-70 °C
• Boiling Point: 373.1°C at 760 mmHg
• Flash Point: 179.5°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 9.17E-06mmHg at 25°C
• Refractive Index: 1.61
• PKA: 4.40±0.10(Predicted)
• CAS DataBase Reference: 2-BENZYL-5-METHYL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-5-METHYL-2H-PYRAZOL-3-YLAMINE(1134-82-3)
• EPA Substance Registry System: 2-BENZYL-5-METHYL-2H-PYRAZOL-3-YLAMINE(1134-82-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 1134-82-3(Hazardous Substances Data)

Usage

General Description

2-Benzyl-5-methyl-2H-pyrazol-3-ylamine is a chemical compound that belongs to the class of pyrazole derivatives. It is characterized by its unique structure, which consists of a benzyl group, a methyl group, and a pyrazole ring. 2-BENZYL-5-METHYL-2H-PYRAZOL-3-YLAMINE has potential applications in the field of medicinal chemistry, as it may exhibit biological activity and could be used as a building block for the synthesis of various pharmaceutical agents. Further research and development of 2-benzyl-5-methyl-2H-pyrazol-3-ylamine could lead to the discovery of new drugs with therapeutic benefits. Additionally, its properties and reactivity make it a valuable intermediate for the production of other organic compounds.

InChI:InChI=1/C11H13N3/c1-9-7-11(12)14(13-9)8-10-5-3-2-4-6-10/h2-7H,8,12H2,1H3

Upstream product

• 34362-22-6 2,3-dichlorobutanenitrile 
• 555-96-4 Benzylhydrazine 
• 100-52-7 benzaldehyde 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 
• 1118-61-2 3-Aminocrotononitrile 
• 1073-62-7 N-benzylhydrazine hydrochloride 
• 2469-99-0 Cyanoaceton 
• 137968-23-1 1-(Benzylamino)-5-methylpyrazole 

Downstream Products

• 1131121-64-6 5-bromo-3-methyl-1-(phenylmethyl)-1H-pyrazolo[3,4-b]pyridine 
• 1620103-05-0 1-benzyl-3-methyl-4-thiocyanato-5-amino-1H-pyrazole 
• 1603826-71-6 1-benzyl-3-methyl-1H-pyrazolo[3,4-d]thiazole-5-carboxamide 
• 1603826-64-7 1-benzyl-3-methyl-1H-pyrazolo[3,4-d]thiazole-5-carbonitrile 
• 1603826-50-1 6-benzyl-4-methyl-6H-pyrazolo[3,4-c]isothiazole-3-carbonitrile 
• 1603826-59-0 (Z)-1-benzyl-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-3-methyl-1H-pyrazol-5-amine 
• 1448705-06-3 V⁽⁶⁶⁵⁾U₀₄₅₁ 
• 1228245-74-6 C₁₉H₁₉N₃O₂ 
• 184172-84-7 5-amino-1-benzyl-3-methyl-4-nitrosopyrazole 
• 92133-92-1 N-(2-Benzyl-5-methyl-2H-pyrazol-3-yl)-4-methyl-benzenesulfonamide 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having pyrazolopyridine structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

The Boulton-Katritzky rearrangement of isocarboxazid

(Chemical Equation Presented) Isocarboxazid rearranges on heating to 5-acetonyl-2-benzyl-4-hydroxy-1,2,3-triazole in DMF at 150°C, in the ionic liquid, [bmin]HSO4- at 100°C or as a melt at 105°C. This is the first reported example of the Boulton-Katritzky rearrangement of an acyl hydrazide.