113440-58-7
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Basic information
- Product Name: Calicheamicin
- Synonyms: Calicheamicin
- CAS NO:113440-58-7
- Molecular Formula:
- Molecular Weight:
- EINECS: N/A
- Product Categories: N/A
- Mol File: 113440-58-7.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Calicheamicin(CAS DataBase Reference)
- NIST Chemistry Reference: Calicheamicin(113440-58-7)
- EPA Substance Registry System: Calicheamicin(113440-58-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 113440-58-7(Hazardous Substances Data)
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113440-58-7 Usage
Definition
Calicheamicins (CLM) is an endiyne antitumor antibiotic isolated from the fermentation broth of the rare Micromonospora actinomycetes.Application
Calicheamicin is extremely toxic to all cells and, in 2000, a CD33 antigen-targeted immunoconjugate N-acetyl dimethyl hydrazide calicheamicin was developed and marketed as targeted therapy against the non-solid tumor cancer acute myeloid leukemia (AML).Check Digit Verification of cas no
The CAS Registry Mumber 113440-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,4,4 and 0 respectively; the second part has 2 digits, 5 and 8 respectively.Calculate Digit Verification of CAS Registry Number 113440-58:
(8*1)+(7*1)+(6*3)+(5*4)+(4*4)+(3*0)+(2*5)+(1*8)=87
87 % 10 = 7
So 113440-58-7 is a valid CAS Registry Number.
113440-58-7Upstream product
113440-58-7Downstream Products
113440-58-7Related news
Synthesis of analogues of Calicheamicin (cas 113440-58-7) and neocarzinostatin chromophore08/15/2019
The work presents a synthetic route to the CD ring of calicheamicin and in the case of neocarzinostatin an approach to a functionalised cyclopentane-1,3-diol containing the naturally occurring naphthoate and a glucosamine motif. In the case of the NCS derivative some biological activity (cytotox...detailed
Cleavage of cellular DNA by Calicheamicin (cas 113440-58-7) γ108/14/2019
It is assumed that the efficient antitumor activity of calicheamicin γ1 is mediated by its ability to introduce DNA double-strand breaks in cellular DNA. To test this assumption we have compared calicheamicin γ1-mediated cleavage of cellular DNA and purified plasmid DNA. Cleavage of purified p...detailed
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Calicheamicin
