1139874-39-7Relevant articles and documents
An enantioselective organocatalytic approach to both enantiomers of lasubine II
Verkade, Jorge M.M.,Van Der Pijl, Ferdi,Willems, Marian M.J.H.P.,Quaedflieg, Peter J.L.M.,Van Delft, Floris L.,Rutjes, Floris P.J.T.
supporting information; experimental part, p. 3207 - 3210 (2009/08/08)
A concise stereoselective route providing access to both enantiomers of the bioactive quinolizidine alkaloid lasubine II has been developed. The enantioselectivity was introduced by taking advantage of a proline-catalyzed asymmetric Mannich reaction. Next, the bicyclic system was constructed via a diastereoselective Mannich cyclization and subsequent ring-closing metathesis as the key steps.