114-83-0Relevant articles and documents
Synthesis of acetamides via oxidative C–C bond cleavage of ketones catalyzed by Cu-immobilized magnetic nanoparticles
Yazdani, Elahe,Pazoki, Farzane,Salamatmanesh, Arefe,Nejad, Masoume Jadidi,Miraki, Maryam Kazemi,Heydari, Akbar
, (2020/07/27)
Copper supported on magnetite nanoparticles modified with environmentally friendly ligand tricine was devised for synthesis of acetamides via C–C oxidative cleavage of ketones with amines. The catalyst was characterized using different techniques, including Fourier transform infrared, X-ray diffraction, scannin electron microscopy, vibrating sample magnetometry, thermogravimetric analysis, and energy dispersive x-ray spectroscopy. The protocol showed relatively high yields of acetamide products. Furthermore, the magnetic recovery of the catalyst rendered the overall process fast and efficient. It was used in the reaction for six consecutive cycles with negligible loss of catalytic activity. This research is the first report of application of magnetic nanocatalysts for synthesis of acetamides from ketones of low activity through a C–C bond cleavage strategy.
The impact of cation structure upon the acidity of triazolium salts in dimethyl sulfoxide
Konstandaras, Nicholas,Dunn, Michelle H.,Guerry, Max S.,Barnett, Christopher D.,Cole, Marcus L.,Harper, Jason B.
supporting information, p. 66 - 75 (2019/12/26)
A series of triazolium salts, selected for their varying electronic and steric properties, were prepared and their pKa values were determined in DMSO at 25 °C using the bracketing indicator method. The effect of each systematic structural variation upon the acidity of the triazolium cation has been considered, in particular examining the effects of systematically altering electronic properties, quantified through the use of Hammett σ parameters. The first pKa value for an azolium salt that generates a mesionic carbene is also reported. These new data allow for the selection of appropriate bases for the deprotonation of such triazolium salts and the potential to correlate the pKa values determined herein with the nucleophilicity of the corresponding carbenes.
Synthesis method for organic synthesis of intermediate acetyl phenylhydrazine
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Paragraph 0011; 0013; 0014; 0015, (2018/07/30)
The invention relates to a synthesis method for organic synthesis of an intermediate acetyl phenylhydrazine. The method mainly includes the steps of: adding 3mol phenylhydrazine into a reaction container and 4-5mol p-iodoacetanilide into a reaction container, performing heating to 90-95DEG C, conducting reflux for 130-150min, lowering temperature to 10-15DEG C, filtering the crystal, conducting washing with a methylamine solution and a dichloromethane solution respectively, performing recrystallization in an ethanol solution, precipitating crystals, conducting filtration, and performing dehydration with a dehydrating agent, thus obtaining the finished product acetyl phenylhydrazine.