114014-15-2 Usage
General Description
Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE is a complex organic compound used primarily in scientific research. Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE acts as a specific inhibitor of calpain, a type of protein-degrading enzyme. Due to its potential to restrain calpain’s activity, it has important applications in studying various biological and pathological processes where these enzymes are involved, such as in neurodegenerative diseases, cardiovascular diseases, and cancer. Its unique structure allows it to effectively bind and interrupt the operation of the calpain molecule. Prior to use, it is often stored as a lyophilized powder ensuring its stability for long-term storage.
Check Digit Verification of cas no
The CAS Registry Mumber 114014-15-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,0,1 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 114014-15:
(8*1)+(7*1)+(6*4)+(5*0)+(4*1)+(3*4)+(2*1)+(1*5)=62
62 % 10 = 2
So 114014-15-2 is a valid CAS Registry Number.
114014-15-2Relevant articles and documents
Development of peptidyl α-keto-β-aldehydes as new inhibitors of cathepsin L - Comparisons of potency and selectivity profiles with cathepsin B
Lynas, John F.,Hawthorne, Susan J.,Walker, Brian
, p. 1771 - 1773 (2007/10/03)
We have utilized previously known substrate and inhibitor specificity profiles for the lysosomal cysteine protease, cathepsin L, to design a new series of putative inhibitors of this enzyme, based on di- and tri-peptidyl α-keto-β-aldehydes. Kinetic evaluation of these compounds revealed Z-Phe-Tyr(OBut)-COCHO, with a K(i)=0.6 nM, to be the most potent, synthetic reversible inhibitor of cathepsin L reported to date. (C) 2000 Elsevier Science Ltd. All rights reserved.
