114079-04-8Relevant articles and documents
Synthesis of Alkylphosphon(othio)ate Analogues of DNA
Roelen, H. C. P. F.,Elst, H. van den,Dreef, C. E.,Marel, G. A. van der,Boom, J. H. van
, p. 2357 - 2360 (2007/10/02)
Easily accessible bis(diisopropylamino)alkylphosphines (alkyl is methyl, n-butyl or n-octyl) are convenient reagents for the synthesis of DNA fragments having an alkylphosphonate or alkylphosphonothioate linkage at a predetermined site in solution and on
1,1-Bis-(4-methoxyphenyl)-1'-pyrenyl methyl (bmpm): A new fluorescent 5' protecting group for the purification of unmodified and modified oligonucleotides
Fourrey,Varenne,Blonski,Dousset,Shire
, p. 5157 - 5160 (2007/10/02)
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OLIGODEOXYNUCLEOSIDE METHYLPHOSPHONATES: SYNTHESIS AND ENZYMIC DEGRADATION
Agrawal, Sudhir,Goodchild, John
, p. 3539 - 3542 (2007/10/02)
The automated synthesis of oligodeoxynucleosides containing methylphosphonate linkages has been improved by using nucleoside methylphosphonamidites as starting materials.It was found that two adjacent methylphosphonate linkages protect an oligomer from degradation by snake venom phosphodiesterase or spleen phosphodiesterase.