114079-44-6

Basic information

• Product Name: 2-Butanol, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-
• CAS NO: 114079-44-6
• Molecular Formula: C20H28O2Si
• Molecular Weight: 328.527
• Mol File: 114079-44-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-Butanol, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanol, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-(114079-44-6)
• EPA Substance Registry System: 2-Butanol, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-(114079-44-6)

Safety Data

• Hazardous Substances Data: 114079-44-6(Hazardous Substances Data)

Upstream product

• 18826-95-4 1.3-butanediol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 97250-25-4 tert-Butyldiphenylsilyl β-hydroxybutanone 
• 121671-72-5 C₂₆H₄₂O₂Si₂ 

Downstream Products

• 807365-26-0 ((S)-4-Benzyloxy-5-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3,3-dimethyl-2-oxo-pentyl)-phosphonic acid dimethyl ester 
• 807365-21-5 (S)-3-Benzyloxy-4-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2,2-dimethyl-butan-1-ol 
• 135413-38-6 (3S,5R,7S)-7-benzyloxy-1-tert-butyldiphenylsiloxy-9-(p-methoxyphenyl)methoxy-8,8-dimethylnonane-3,5-diol 
• 135304-57-3 (3S,5R,7S)-3-benzyloxy-9-tert-butyldiphenylsiloxy-1-(p-methoxyphenyl)methoxy-2,2-dimethyl-5,7-isopropylidenedioxynonane 
• 135304-56-2 (5S,7S)-7-benzyloxy-1-tert-butyldiphenylsiloxy-5-hydroxy-9-(p-methoxyphenyl)methoxy-8,8-dimethylnonan-3-one 
• 884345-38-4 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-(2-trimethylsilylethoxymethoxy)ethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxy-3-(2-trimethylsilylethoxymethoxy)heptadec-16-ene 
• 884345-37-3 (3S,5R,7S,9S,11S,15R)-7-benzyloxy-1-tert-butyldiphenylsilyloxy-13-[(Z)-2-hydroxyethylidene]-5,9-epoxy-11,15-epoxy-8,8-dimethyl-9-methoxyheptadec-16-en-3-ol 
• 884345-36-2 (S)-4-Benzyloxy-1-{(2S,6R)-4-[2-(tert-butyl-dimethyl-silanyloxy)-eth-(Z)-ylidene]-6-vinyl-tetrahydro-pyran-2-yl}-5-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3,3-dimethyl-pentan-2-one 
• 884345-35-1 (S)-4-Benzyloxy-1-{(2S,6R)-4-[2-(tert-butyl-dimethyl-silanyloxy)-eth-(Z)-ylidene]-6-hydroxymethyl-tetrahydro-pyran-2-yl}-5-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3,3-dimethyl-pentan-2-one 

Relevant articles and documents

Interrupting the Barton?McCombie reaction: Aqueous deoxygenative trifluoromethylation of o-alkyl thiocarbonates

The site-selective trifluoromethylation of aliphatic systems remains an important challenge. This work describes a light-driven, copper-mediated trifluoromethylation of O-alkyl thiocarbonates. The reaction provides broad functional group tolerance (e.g., alkyne, alkene, phenol, free alcohol, electron-rich and -deficient arenes), thereby offering orthogonality and practicality for trifluoromethylation. A radical organometallic mechanism is proposed.

NOVEL PHARMACEUTICAL COMPRISING HETEROAROMATIC AMIDE DERIVATIVE OR SALT THEREOF

PROBLEM TO BE SOLVED: To provide a compound useful for treating or preventing disease associated with voltage-dependent sodium channel (Nav1.7) such as disease involving a pain, disease involving an itch, autonomic nerve-associated disease, or a pharmaceutical composition thereof. SOLUTION: The present disclosure provides a compound illustrated by the following formula, and a pharmaceutical composition containing the same. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Mild deprotection of PMB ethers using tert-butyl bromide

A convenient and high yielding method for the cleavage and scavenging of p-methoxybenzyl protecting group of several alcohols using tert-butyl bromide in refluxing acetonitrile is described. Under these mild conditions other protecting groups such as acid sensitive allyl, benzyl, and Me3CPh2Si ethers, or isopropylidene acetals were unchanged. Interestingly, a selective alkoxy-PMB cleavage was observed in the presence of a PMB phenoxy ether.