114150-50-4

Basic information

• Product Name: 4,6-dioxo-6-(4-methylphenyl)hexanoic acid
• Synonyms: 4,6-dioxo-6-(4-methylphenyl)hexanoic acid
• CAS NO: 114150-50-4
• Molecular Weight: 234.252
• Mol File: 114150-50-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4,6-dioxo-6-(4-methylphenyl)hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dioxo-6-(4-methylphenyl)hexanoic acid(114150-50-4)
• EPA Substance Registry System: 4,6-dioxo-6-(4-methylphenyl)hexanoic acid(114150-50-4)

Safety Data

• Hazardous Substances Data: 114150-50-4(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 1339036-09-7 4-isopropylphenyl 3-[5-(4-methylphenyl)-1-quinolin-2-yl-1H-pyrazol-3-yl]propanoate 
• 1339036-07-5 ethyl 1-{3-[5-(4-methylphenyl)-1-quinolin-2-yl-1H-pyrazol-3-yl]propanoyl}piperidine-4-carboxylate 
• 1339036-05-3 4-isopropylphenyl 3-[5-(4-methylphenyl)-1-phenyl-1H-pyrazol-3-yl]propanoate 
• 1339036-02-0 ethyl 1-{3-[5-(4-methylphenyl)-1-phenyl-1H-pyrazol-3-yl]propanoyl}piperidine-4-carboxylate 
• 1339035-97-0 3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]-6-methoxypyridazine 
• 1339035-91-4 2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline 
• 1339035-84-5 1-(4-tert-butylbenzyl)-4-{3-[5-(4-methylphenyl)-1-phenyl-1H-pyrazol-3-yl]propanoyl}piperazine 
• 1339035-79-8 1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine 
• 1339035-74-3 3-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]-6-chloropyridazine 
• 1339035-47-0 4-(trifluoromethoxy)phenyl 3-[1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoate 
• 1339035-45-8 4-[4-(trifluoromethyl)phenoxy]phenyl 3-[1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoate 
• 1339035-44-7 4-isopropylphenyl 3-[1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoate 
• 1339035-41-4 3-chloro-6-[3-{3-[4-(ethylsulfonyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]pyridazine 
• 1339035-40-3 3-[1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]-N-(6-morpholin-4-ylpyridin-3-yl)propanamide 

Relevant articles and documents

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Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation

A set of 25 derivatives of 3-[1-(6-substituted-pyridazin-3-yl)-5-(4- substitutedphenyl)-1H-pyrazol-3-yl]propanoic acids has been synthesized and evaluated for their in vitro cyclooxygenase-1/2 (COX-1/ 2) inhibitory activity using assays with purified COX-1 and COX-2 enzymes as well as for their 5-lipoxygenase (5-LO)-mediated LTB4 formation inhibitory activity using an assay with activated human polymorphonuclear leukocytes (PMNL). Among the synthesized compounds, especially 4g showed COX-1 (IC50 = 1.5 μM) and COX-2 (IC50 = 1.6 μM) inhibitory activity, whereas compounds 4b and 4 f resulted in the inhibition of 5-LO-mediated LTB4 formation at 14 μM and 12 μM IC50 values, respectively, without any significant inhibition on COX isoforms. ECV · Editio Cantor Verlag.