114153-09-2Relevant articles and documents
Ortho lithiation of N-pivaloylfluoroanilines as a useful tool for either selective methylation or benzoxazole synthesis
Yoshida, Yasuo,Hamada, Yusuke,Umezu, Kazuto,Tabuchi, Fumiya
, p. 958 - 961 (2004)
Lithiation of N-pivaloyl-3,4-difluoroaniline (1a) with a slight excess of 2 mole equiv of n-butyllithium followed by methylation was studied. The reaction was found to be useful for either the selective methylation of 3,4-difluoroaniline or the synthesis of benzoxazole derivatives, depending on the reaction temperature. In the reaction of N-pivaloyl-3-chloro-4-fluoroaniline (1b) and N-pivaloyl-3-fluoroaniline (1c), the reaction proceeded rather sluggishly but benzoxazole formation predominated.
A practical route to C-8 substituted fluoroquinolones
Carretero,Garcia Ruano,Vicioso
, p. 7373 - 7382 (2007/10/02)
The ortho metalation of N-(tert-butoxycarbonyl)-3,4-difluoroaniline, with t-BuLi at -78°C in THF occurred regioselectively at C-2 position. The resulting lithiated species reacted with a variety of electrophiles to give 2-substituted-3,4-difluoranilines i
1-Cyclopropyl-6-fluoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives
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, (2008/06/13)
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: STR1 wherein R2 is a heterocyclic group: STR2 in which RA is H, C1 -C6 alkyl or phenyl (C1 -C6) alkyl, RB is 2-ox