1142208-49-8

Basic information

• Product Name: C₁₅H₈ClF₂N₃
• CAS NO: 1142208-49-8
• Molecular Weight: 303.698
• Mol File: 1142208-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₈ClF₂N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₈ClF₂N₃(1142208-49-8)
• EPA Substance Registry System: C₁₅H₈ClF₂N₃(1142208-49-8)

Safety Data

• Hazardous Substances Data: 1142208-49-8(Hazardous Substances Data)

Upstream product

• 1897-50-3 5-chloro-2,4,6-trifluoroisophthalonitrile 
• 106-49-0 p-toluidine 

Relevant articles and documents

Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives

A series of polyhalo acridone heterocyclic compounds were synthesized and evaluated for their in vitro antitumor activity. It was noteworthy that halogen atoms were present at the 1, 3 and 4 sites of the compounds, and an amide group or a cyano group was at the 2 site. The antitumor bioactivity screening revealed that all the compounds exhibited potent antitumor activity. In particular, compounds 4d, 4o, 5j and 5k showed good antineoplastic selectivity, with a survival rate above 50% in NIH3T3 mouse embryonic cells. The IC50 values were 8.69-13.06 μM in A431 cells. A preliminary assessment of the structure-selectivity relationship of the compounds was also performed.