1142947-81-6

Basic information

• Product Name: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[3-(4-Methyl-1-piperazinyl)phenyl]-
• Synonyms: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[3-(4-Methyl-1-piperazinyl)phenyl]-;4-Chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
• CAS NO: 1142947-81-6
• Molecular Formula: C₁₇H₁₉ClN₆
• Molecular Weight: 342.82596
• Mol File: 1142947-81-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[3-(4-Methyl-1-piperazinyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[3-(4-Methyl-1-piperazinyl)phenyl]-(1142947-81-6)
• EPA Substance Registry System: 7H-Pyrrolo[2,3-d]pyriMidin-2-aMine, 4-chloro-N-[3-(4-Methyl-1-piperazinyl)phenyl]-(1142947-81-6)

Safety Data

• Hazardous Substances Data: 1142947-81-6(Hazardous Substances Data)

Usage

General Description

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-N-[3-(4-methyl-1-piperazinyl)phenyl]- is a chemical compound with the molecular formula C17H19ClN8. It is a derivative of pyrrolopyrimidine and contains an amine group as well as a chlorine atom. 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-N-[3-(4-methyl-1-piperazinyl)phenyl]- is commonly used in the pharmaceutical industry for the development of potential drug candidates. It may possess biological activities and has been studied for its potential in the treatment of various diseases and conditions. Additionally, it is also used as a research tool in medicinal chemistry and drug discovery.

Upstream product

• 1142947-80-5 2-[3-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol 

Downstream Products

• 1142946-79-9 4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1142947-27-0 [3-(4-methyl-piperazin-1-yl)-phenyl]-[4-(4-methyl-thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine 
• 1142947-29-2 (4-benzo[b]thiophen-2-yl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine 
• 1142946-99-3 tert-butyl 2-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate 
• 1142947-55-4 5-(2-(3-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-methylthiophene-2-carbonitrile 
• 1142947-47-4 2-(2-(3-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzo[b]thiophene-6-carbonitrile 
• 1142947-28-1 {4-[5-(3,5-dimethyl-isoxazol-4-yl)-thiophen-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine 
• 1142947-51-0 1-(2-(2-(3-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzo[b]thiophen-5-yl)pentan-1-one 

Relevant articles and documents

PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS

Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.