1142953-56-7 Usage
Functional Group
Pyrazole derivative with a 2-bromoethyl group
Utility
Organic Synthesis: Used in organic synthesis.
Pharmaceutical Research: Employed in pharmaceutical research.
Applications
Intermediate: Useful as an intermediate in the preparation of various pharmaceuticals and agrochemicals.
Building Block: Used as a building block in the synthesis of biologically active compounds.
Drug Development: Assists in the development of new drug candidates.
Significance
Chemical Research: Valuable tool for chemists and researchers in medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 1142953-56-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,2,9,5 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1142953-56:
(9*1)+(8*1)+(7*4)+(6*2)+(5*9)+(4*5)+(3*3)+(2*5)+(1*6)=147
147 % 10 = 7
So 1142953-56-7 is a valid CAS Registry Number.
1142953-56-7Relevant articles and documents
Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists
Dounay, Amy B.,Barta, Nancy S.,Bikker, Jack A.,Borosky, Susan A.,Campbell, Brian M.,Crawford, Terry,Denny, Lynne,Evans, Lori M.,Gray, David L.,Lee, Pil,Lenoir, Edward A.,Xu, Wenjian
scheme or table, p. 1159 - 1163 (2009/08/07)
Aminopyrimidine 2 (4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-cyclopropylpyrimidin-2-amine) emerged from a high throughput screen as a novel 5-HT1A agonist. This compound showed moderate potency for 5-HT1A in binding and functional assays, as well as moderate metabolic stability. Implementation of a strategy for improving metabolic stability by lowering the lipophilicity (c Log D) led to identification of methyl ether 31 (4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(2-methoxyethyl)pyrimidin-2-amine) as a substantially improved compound within the series.
