1145869-36-8 Usage
Description
1-(4'-azido-3'-O-benzoyl-2'-deoxy-2'-fluoro-5'-iodo-β-D-arabinofuranosyl)uracil is a complex chemical compound that features an azido group, a benzoyl group, a deoxy group, a fluoro group, a iodo group, and a uracil moiety. This modified form of uracil has various substitutions and additions, making it a potentially valuable compound for medicinal and pharmaceutical research. The presence of these diverse functional groups can significantly alter the chemical and biological properties of the molecule, potentially influencing its interactions with other compounds and biological systems.
Uses
Used in Pharmaceutical Research:
1-(4'-azido-3'-O-benzoyl-2'-deoxy-2'-fluoro-5'-iodo-β-D-arabinofuranosyl)uracil is used as a research compound for its potential therapeutic applications. The unique combination of functional groups in this molecule may provide novel avenues for the development of new drugs or therapies.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4'-azido-3'-O-benzoyl-2'-deoxy-2'-fluoro-5'-iodo-β-D-arabinofuranosyl)uracil is used as a starting material or a building block for the synthesis of more complex molecules with specific biological activities. Its diverse functional groups can be exploited to create new compounds with tailored properties for various therapeutic targets.
Used in Drug Design:
1-(4'-azido-3'-O-benzoyl-2'-deoxy-2'-fluoro-5'-iodo-β-D-arabinofuranosyl)uracil is used as a structural element in drug design, where its unique properties can be leveraged to create new drugs with improved efficacy, selectivity, and safety profiles.
Used in Biochemical Studies:
1-(4'-azido-3'-O-benzoyl-2'-deoxy-2'-fluoro-5'-iodo-β-D-arabinofuranosyl)uracil can also be used in biochemical studies to investigate its interactions with various biological systems, such as enzymes, receptors, or other macromolecules. Understanding these interactions can provide insights into the molecular mechanisms underlying its potential therapeutic effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1145869-36-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,5,8,6 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1145869-36:
(9*1)+(8*1)+(7*4)+(6*5)+(5*8)+(4*6)+(3*9)+(2*3)+(1*6)=178
178 % 10 = 8
So 1145869-36-8 is a valid CAS Registry Number.
1145869-36-8Relevant articles and documents
Synthesis of new 2′-deoxy-2′-fluoro-4′-azido nucleoside analogues as potent anti-HIV agents
Wang, Qiang,Hu, Weidong,Wang, Shuyang,Pan, Zhenliang,Tao, Le,Guo, Xiaohe,Qian, Keduo,Chen, Chin-Ho,Lee, Kuo-Hsiung,Chang, Junbiao
, p. 4178 - 4183 (2011)
We prepared 1-(4′-azido-2′-deoxy-2′-fluoro-β-d- arabinofuranosyl)cytosine (10) and its hydrochloride salt (11) as potential antiviral agents based on the favorable antiviral profiles of 4′-substituted nucleosides. Compounds 10 and 11 were synthesized from 1,3,5-O-tribenzoyl-2-deoxy-2-fluoro-d-arabinofuranoside in multiple steps, and their structures were unequivocally established by IR, 1H NMR, 13C NMR, and 19F NMR spectroscopy, HRMS, and X-ray crystallography. Compounds 10 and 11 exhibited potent anti-HIV-1 activity (EC50: 0.3 and 0.13 nM, respectively) without significant cytotoxicity in concentrations up to 100 μM. Compound 11 exhibited extremely potent anti-HIV activity against NL4-3 (wild-type), NL4-3 (K101E), and RTMDR viral strains, with EC50 values of 0.086, 0.15, and 0.11 nM, respectively. Due to the high potency of 11, it was also screened against an NIH Reagent Program NRTI-resistant virus panel containing eleven mutated viral strains and for cytotoxicity against six different human cell lines. The results of this screening indicated that 11 is a novel NRTI that could be developed as an anti-AIDS clinical trial candidate to overcome drug-resistance issues.
Azido nucleosides and nucleotide analogs
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Page/Page column 100; 101, (2016/06/13)
Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
