1145881-54-4

Basic information

• Product Name: 1,3-difluoro-2-iodo-4-nitrobenzene
• Synonyms: 1,3-difluoro-2-iodo-4-nitrobenzene
• CAS NO: 1145881-54-4
• Molecular Weight: 284.989
• Mol File: 1145881-54-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,3-difluoro-2-iodo-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-difluoro-2-iodo-4-nitrobenzene(1145881-54-4)
• EPA Substance Registry System: 1,3-difluoro-2-iodo-4-nitrobenzene(1145881-54-4)

Safety Data

• Hazardous Substances Data: 1145881-54-4(Hazardous Substances Data)

Usage

Appearance

Yellow solid

Solubility

Insoluble in water, soluble in organic solvents

Uses

a. Building block in the synthesis of pharmaceuticals
b. Building block in the synthesis of agrochemicals
c. Production of dyes
d. Intermediate in organic synthesis

Reactivity

Highly reactive

Safety precautions

Potential to cause irritation to skin, eyes, and respiratory system; should be handled with caution

Upstream product

• 446-35-5 2,4-Difluoronitrobenzene 
• 1426659-27-9 (2,6-difluoro-3-nitrophenyl)zinc pivalate 
• 372-18-9 1,3-Difluorobenzene 
• 13697-89-7 2,6-difluoroiodobenzene 

Downstream Products

• 1437316-91-0 2,4-difluoro-3-iodoaniline 
• 1392429-92-3 N-(2,4-difluoro-3-iodophenyl) propane-1-sulfonamide 
• 1437316-92-1 N-(2,4-difluoro-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide 
• 2183470-12-2 N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide 
• 1300015-01-3 6,8-dimethoxy-7-o-tolylquinoline 
• 1300014-94-1 6,8-dihydroxy-7-o-tolylquinoline 
• 1300014-97-4 2-iodo-1,3-dimethoxy-4-nitrobenzene 

Relevant articles and documents

HETEROCYCLIC COMPOUND

Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF

The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.

TMPZnOPiv?LiCl: A new base for the preparation of air-stable solid zinc pivalates of sensitive aromatics and heteroaromatics

A wide range of aryl and heteroaryl zinc pivalates bearing sensitive functionalities were prepared by selective metalation using TMPZnOPiv?LiCl, a new hindered zinc amide base. The new zinc reagents are easy-to-handle solids, which maintain their activity almost entirely (>95%) after 4 h of air exposure and smoothly undergo Negishi cross-couplings and reactions with various electrophiles such as Cu(I)-catalyzed acylations and allylations.