1146981-24-9

Basic information

• Product Name: 1-{[(2,6-dichlorophenyl)-3-(2-chloro-6-methylquinolin-3-yl)]methylene}-1,3-dihydroindol-2-one
• CAS NO: 1146981-24-9
• Molecular Weight: 465.766
• Mol File: 1146981-24-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-{[(2,6-dichlorophenyl)-3-(2-chloro-6-methylquinolin-3-yl)]methylene}-1,3-dihydroindol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{[(2,6-dichlorophenyl)-3-(2-chloro-6-methylquinolin-3-yl)]methylene}-1,3-dihydroindol-2-one(1146981-24-9)
• EPA Substance Registry System: 1-{[(2,6-dichlorophenyl)-3-(2-chloro-6-methylquinolin-3-yl)]methylene}-1,3-dihydroindol-2-one(1146981-24-9)

Safety Data

• Hazardous Substances Data: 1146981-24-9(Hazardous Substances Data)

Upstream product

• 73568-27-1 2-chloro-6-methylquinoline-3-carbaldehyde 
• 15362-40-0 1-(2,6-dichlorophenyl)indolin-2-one 
• 15308-01-7 2-chloro-N-(2',6'-dichlorophenyl)-N-phenylacetamide 
• 15307-93-4 N-phenyl-2,6-dichloroaniline 

Relevant articles and documents

In vitro cytotoxicity evaluation of diversely substituted N-aryl-2-oxindoles

In continuation with our previous work, structurally diverse 2-indolinones bearing 2,6-dichloroaryl fragment at N 1 and (hetero)aryl benzylidene at C3 were evaluated for their antitumor activity on a panel of cancer cell lines such as MCF-7 (breast), MiapaCa2 (pancreas), KB (oral), HuTu80 (stomach), L132 (lung), B16F10 (melanoma), and Molt4 (leukemia) from various human organs. Among the screened compound library, molecules 4e, 4k, and 4r have shown excellent cytotoxicity on a stomach cancer cell line. Moreover, a significant number of compounds have also shown promising cytotoxicity on pancreas and oral cancer cell lines.