114772-66-6

Basic information

• Product Name: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl]-, methyl ester
• CAS NO: 114772-66-6
• Molecular Formula: C23H23ClN2O3
• Molecular Weight: 410.9
• Mol File: 114772-66-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl]-, methyl ester(114772-66-6)
• EPA Substance Registry System: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(2-butyl-4-chloro-5-formyl-1H-imidazol-1-yl)methyl]-, methyl ester(114772-66-6)

Safety Data

• Hazardous Substances Data: 114772-66-6(Hazardous Substances Data)

Upstream product

• 83857-96-9 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 114772-43-9 2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole 
• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 624-31-7 4-tolyl iodide 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 7148-03-0 o-tolylbenzoic acid 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 
• 74201-13-1 N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide 
• 84392-32-5 4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole 
• 579-75-9 2-Methoxybenzoic acid 
• 21615-34-9 2-Methoxybenzoyl chloride 

Downstream Products

• 114772-43-9 2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole 
• 152147-96-1 2-butyl-1-<(2'-carbomethoxy<1,1'-biphenyl>-4-yl)methyl>-1H-imidazole-5-carboxaldehyde 
• 114772-67-7 1-[(2'-carbomethoxybiphenyl-4-yl)-methyl]-2-(1-bromobutyl)-4-chloroimidazole-5-carboxaldehyde 
• 114772-69-9 1-[(2'-Carbomethoxybiphenyl-4-yl)methyl]-2-(1-trans-butenyl)-4-chloro-5-hydroxymethylimidazole 
• 114772-68-8 2-(1-trans-butenyl)-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxaldehyde 
• 114798-32-2 2-(1E-Butenyl)-4-chloro-1-[(2'-carboxybiphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole 

Relevant articles and documents

Potent Nonpeptide Angiotensin II Receptor Antagonists. 2. (1-Carboxybenzyl)imidazole-5-acrylic Acids

The further evolution of the imidazole-5-acrylic acid series of nonpeptide angiotensin II receptor antagonists is detailed (for Part 1, see: J.Med.Chem. 1992, 35, 3858).Modifications of the N-benzyl ring substitution were undertaken in an effort to mimic the Tyr4 residue of angiotensin II.Introduction of a p-carboxylic acid on the N-benzyl ring resulted in the discovery of compounds with nanomolar affinity for the receptor and good oral activity.SAR studies of these potent antagonists revealed that the thienyl ring, the (E)-acrylic acid, and the imidazole ring in addition to the two acid groups were important for high potency.Also, overlay comparisons of the parent diacid with both angiotensin II and a representative biphenylyltetrazole nonpeptide angiotensin II receptor antagonist are presented.The parent diacid analog, SKF 108566 or (E)-3--2-propenoic acid, is currently in clinical development for the treatment of hypertension.

Treatment of congestive heart failure with angiotensin 11 receptor blocking imidazoles

Substituted imidazoles such as STR1 are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.