114826-94-7Relevant articles and documents
Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads
Hamon, Nadège,Slusarczyk, Magdalena,Serpi, Michaela,Balzarini, Jan,McGuigan, Christopher
, p. 829 - 838 (2015)
2-Deoxy-α-d-ribose-1-phosphate is of great interest as it is involved in the biosynthesis and/or catabolic degradation of several nucleoside analogues of biological and therapeutic relevance. However due to the lack of a stabilising group at its 2-position, it is difficult to synthesize stable prodrugs of this compound. In order to overcome this lack of stability, the synthesis of carbasugar analogues of 2-deoxyribose-1-phosphate was envisioned. Herein the preparation of a series of prodrugs of two carbocyclic analogues of 2-deoxyribose-1-phosphate using the phosphoramidate ProTide technology, along with their biological evaluation against HIV and cancer cell proliferation, is reported.
New convergent synthesis of carbocyclic nucleoside analogues
Ludek, Olaf R.,Meier, Chris
, p. 2101 - 2109 (2007/10/03)
Two convergent approaches towards the synthesis of carbocyclic nucleoside analogs will be described. Both approaches start from the stereochemically pure cyclopentenol 8 that has been prepared enantioselectively from an alkylated cyclopentadiene. Using these approaches, carbocyclic analogues of dT, FdU and BVdU have been prepared. Moreover, the conversion into the cycloSalpronucleotide and the corresponding nucleotide will be presented for one example.
The first stereospecific synthesis of (+)-(1R, 2S, 4R)-4-amino-2-hydroxy-1-cyclopentanemethanol and (+)-carbocyclic thymidine
Otvos,Beres,Sagi,Tomoskozi,Gruber
, p. 6381 - 6384,6381-6384 (2007/10/02)
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