114856-02-9

Basic information

• Product Name: Boc-Ala-Lys(Z)-OBzl
• Synonyms: Boc-Ala-Lys(Z)-OBzl
• CAS NO: 114856-02-9
• Molecular Weight: 541.645
• Mol File: 114856-02-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Boc-Ala-Lys(Z)-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Ala-Lys(Z)-OBzl(114856-02-9)
• EPA Substance Registry System: Boc-Ala-Lys(Z)-OBzl(114856-02-9)

Safety Data

• Hazardous Substances Data: 114856-02-9(Hazardous Substances Data)

Upstream product

• 2389-45-9 Boc-Lys(Z)-OH 
• 100-39-0 benzyl bromide 
• 15761-38-3 L-N-Boc-Ala 
• 77236-13-6 N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester 
• 6366-70-7 N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride 
• 24458-14-8 Lys(Z)-OBzl 
• 66024-53-1 BOC-Ala-POBT 
• 3392-05-0 Boc-Ala-O-N-hydroxysuccinimide 

Downstream Products

• 860020-54-8 N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gly-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 860020-53-7 N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Ala-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 860020-55-9 N-[1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2-yl)phenyl-4-yl]oxyacetyl-Gln-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202410-99-9 Boc-Pro-Ala-Lys(Z)-OBzl 
• 202411-01-6 Boc-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202411-03-8 Boc-Ala-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 202411-04-9 Boc-Gln-Arg(Tos)-Pro-Ala-Lys(Z)-OBzl 
• 713524-12-0 Boc-Gly-Arg(NO₂)-Pro-Ala-Lys(Z)-OBzl 

Relevant articles and documents

NOVEL COMPOUND WITH EFFECTS OF THROMBOLYSIS, FREE RADICAL SCAVENGING AND THROMBUS-TARGETING AS WELL AS PREPARATION METHOD AND USE THEREOF

The present invention discloses a novel compound with effects of thrombolysis, free radical scavenging and thrombus-targeting, as well as a preparation method and use thereof. The compound is a ternary conjugate formed by conjugating a thrombolytic peptide, a free radical scavenger and a thrombus-targeting/antithrombotic peptide together via a linking arm. The present invention also discloses a pharmaceutical composition containing the compounds, wherein the compounds form a nanospherical structure.

Synthesis and biological activity of nitronyl nitroxide containing peptides

[1-(1′,3′-Dioxyl-4′,4′,5′, 5′-tetramethyldihydroimidazol-2-yl)-phenyl-4-yl]oxyacetic acid (4), a nitronyl nitroxide, and its peptide derivatives, N-[1-(1′,3′-dioxyl- 4′,4′,5′,5′-tetramethyldihydroimidazol-2-yl) -phenyl-4-yl]oxyacetyl-ARPAK (9a), -GRPAK (9b), and -QRPAK (9c), were synthesized and characterized. Judging from the results of electron spin resonance analysis, the newly synthesized nitronyl nitroxide containing peptides, 9a, 9b, and 9c, demonstrated the characteristics of free radicals. The free radical scavenging activities of 9a, 9b, and 9c were assessed using in vitro free radical scavenging tests. The thrombolysis effect of 9a, 9b, and 9c was evaluated using an euglobulin clot lysis test, a fibrinolytic lysis test, and in vivo thrombolysis tests. Results indicated that these nitronyl nitroxide containing peptides possessed both free radical scavenging activity and thrombolytic activity.

Identification, synthesis and bioassay for the metabolites of P6A

The metabolites Ala-Arg-Pro-Ala-OH, Ala-Arg-Pro-OH, Arg-Pro-Ala-Lys-OH and Pro-Ala-Lys-OH were identified by HPLC/ESI/MS from the in vivo blood of Ala-Arg-Pro-Ala-Lys-OH (P6A) received mice. The in vitro incubation of P6A in the blood of mice the same met