114883-85-1

Basic information

• Product Name: 2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-, (2S)-
• CAS NO: 114883-85-1
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.272
• Mol File: 114883-85-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-, (2S)-(114883-85-1)
• EPA Substance Registry System: 2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-, (2S)-(114883-85-1)

Safety Data

• Hazardous Substances Data: 114883-85-1(Hazardous Substances Data)

Upstream product

• 31795-93-4 N-benzyl-L-proline 
• 955-40-8 N-benzyl-L-proline ethyl ester 
• 147-85-3 L-proline 
• 100-44-7 benzyl chloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 34079-31-7 Z-Pro-NH₂ 
• 100-39-0 benzyl bromide 
• 7531-52-4 L-prolinamide 
• 113304-84-0 N-benzyl-(S)-proline methyl ester 

Downstream Products

• 928056-25-1 1-benzyl-pyrrolidine-2-carbonitrile 
• 141774-70-1 (S)-1-pyrrolidin-2-ylmethyl-carbamic acid tert-butyl ester 
• 342876-81-7 (R)-N-(1-benzyl-2-pyrrolidinylmethyl)-tert-butoxycarbamide 
• 69500-64-7 (S)-2-Aminomethylpyrrolidin 
• 96948-23-1 1-[(2S)-N-Benzylpyrrolidin-2-yl]methanamine 

Relevant articles and documents

CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of chemokine receptor activity.

Amidation of esters assisted by Mg(OCH3)2 or CaCl2

Magnesium methoxide (Mg(OCH3)2) and calcium chloride have been shown to facilitate the direct aminolysis of esters by ammonia to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters were converted to the corresponding carboxamides in good yields. Reactions have been run on a larger scale and without the safety liability inherent in the use of magnesium nitride (Mg3N2). Ammonium chloride and amine hydrochlorides have been used successfully in the place of ammonia with magnesium methoxide.

Catalytic epoxidation of unfunctionalized alkenes by dinuclear nickel(II) complexes

The synthesis, crystal and molecular structure and catalytic activity in epoxidation reactions of new dinuclear nickel(II)-complexes, octahedral μ-diacetato-μ-[2,6-bis[N-2-2'-pyridylethyl)formimidoyl]phenolato]bis nickel(II)·perchlorate·methanol (6) and square planar (μ-hydroxo-μ-[2,6-bis[N-((S)-1-benzyl-2-yl-pyrrolidine)formimidoyl]p henolato]bisnickel(II)·bisperchlorate (7), are described. For the preparation of 7 a new 5-step route for homochiral bisamine (S)-benzyl-2-aminomethyl-pyrrolidine (19) was developed starting from (S)-proline. Epoxidation of unfunctionalized alkenes with sodium hypochlorite and tert-butyl hydroperoxide as terminal oxidants was effectively catalyzed with bisnickel(II)-complexes 6 and 7, and a turnover of 165 was reached using trans-β-methylstyrene (34). The epoxidations probably proceed via a radical intermediate (such as OCl·) and no enantioselectivity is obtained under phase transfer conditions. In epoxidation reactions employing tert-butyl hydroperoxide as terminal oxidant a turnover of 43 was obtained with trans-stilbene (30) as substrate. Unexpectedly in the case of styrene (29) 1,2-bis-(tert-butylperoxy)ethylbenzene (59) was isolated as the major product.