1149-57-1

Basic information

• Product Name: 4-[2-(pyridin-2-yl)ethenyl]phenyl acetate
• CAS NO: 1149-57-1
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.2692
• Mol File: 1149-57-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 377.9°C at 760 mmHg
• Flash Point: 182.4°C
• Density: 1.175g/cm³
• Vapor Pressure: 6.53E-06mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 4-[2-(pyridin-2-yl)ethenyl]phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(pyridin-2-yl)ethenyl]phenyl acetate(1149-57-1)
• EPA Substance Registry System: 4-[2-(pyridin-2-yl)ethenyl]phenyl acetate(1149-57-1)

Safety Data

• Hazardous Substances Data: 1149-57-1(Hazardous Substances Data)

Upstream product

• 109-06-8 α-picoline 
• 108-24-7 acetic anhydride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 878-00-2 4-formylphenyl acetate 
• 38700-15-1 triphenyl-(2-pyridylmethyl)phosphonium chloride 

Downstream Products

• 1209-03-6 4-[2-(2-pyridinyl)ethenyl]phenol 
• 1257420-05-5 4-(6-(4-(2-(2-pyridinyl)vinyl)phenoxy)hexyloxy)aniline 
• 1257420-03-3 2-(4-(6-bromohexyloxy)styryl)pyridine 
• 1257420-04-4 t-butyl 4-(6-(4-(2-(2-pyridinyl)vinyl)phenoxy)hexyloxy)phenylcarbamate 
• 1257420-06-6 2-(4-(6-(4-nitrophenoxy)hexyloxy)styryl)pyridine 
• 1257405-68-7 (2S)-2-((E)-2-(4-acetoxyphenyl)vinyl)piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Borane-Catalyzed Chemoselective and Enantioselective Reduction of 2-Vinyl-Substituted Pyridines

Herein, we report that highly chemoselective and enantioselective reduction of 2-vinyl-substituted pyridines has been achieved for the first time. The reaction, which uses chiral spiro-bicyclic bisboranes as catalysts and HBpin and an acidic amide as reducing reagents, proceeds through a cascade process involving 1,4-hydroboration followed by transfer hydrogenation of a dihydropyridine intermediate. The retained double bond in the reduction products permits their conversion to natural products and other useful heterocyclic compounds by simple transformations.

Discovery of novel picolinamide-based derivatives as novel VEGFR-2 kinase inhibitors: Synthesis,: in vitro biological evaluation and molecular docking

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has emerged as an attractive target for cancer therapy. In our effort, a novel series of picolinamide-based derivatives were designed and synthesized as potent and effective VEGFR-2 inhibitors. All the newly prepared compounds were evaluated in vitro for their antiproliferative activity against A549 and HepG2 cell lines. Among the new compounds, 8j and 8l exhibited better activity against both A549 and HepG2 cell lines. Molecular docking was performed to investigate the binding capacity and binding mode with VEGFR-2 (PDB code: 4ASD).

Comparative syntheses of arylamine monomer with styrylpyridyl photo-crosslinker of polyarylamine for OLED hole-injection material

A new arylamine monomer with photo-crosslinkable styrylpyridinyl moiety of conjugated polyarylamine for OLED hole injection material was synthesized through two synthetic routes, BOC-amine protection/deprotection and nitro group reduction methods. Both sy