114977-28-5Relevant articles and documents
Synthesis of Taxol and Docetaxel by Using 10-Deacetyl-7-xylosyltaxanes
Xue, Baoyu,Zhao, Junhong,Fan, Yange,Chen, Shipeng,Li, Wenfeng,Chen, Jin,Li, Zheng,Wang, Hongxing,Kong, Hongjun
, (2020/02/05)
A mixture of taxols was prepared from 10-deacetyl-7-xylosyltaxanes by three-step reactions: redox, acetylation, and deacetylation. The mixture was separated by column chromatography on silica gel to afford Taxol, Taxol B (Cephalomannine) and Taxol C. The mixture of Taxol B and Taxol C was converted to Docetaxel by Schwartz's reagent. The structures of Taxol and Docetaxel were characterized by HPLC, 1H-NMR, 13C-NMR and MS. This synthetic process has expanded the source of biomass for the chemical semi-synthesis of Taxol and Docetaxel, reduced the production costs, and increased the biomass resource of taxanes.
Method for purifying docetaxel
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Paragraph 0051-0053, (2019/07/04)
The invention discloses a method for purifying docetaxel. A docetaxel solid precipitates from a dichloromethane and toluene mixed solution. The purifying method has the advantages of great reduction of the single content of every impurity in docetaxel, introduction of few impurities, improvement of the purity of the product, and high yield, and is very suitable for industrial large-scale production, and the obtained product meets preparation demands, and can be directly used to prepare a docetaxel injection.
Formulation optimization of an ephrin A2 targeted immunoliposome encapsulating reversibly modified taxane prodrugs
Huang, Zhaohua Richard,Tipparaju, Suresh Kumar,Kirpotin, Dmitri B.,Pien, Christine,Kornaga, Tad,Noble, Charles O.,Koshkaryev, Alexander,Tran, Jimmy,Kamoun, Walid S.,Drummond, Daryl C.
, p. 47 - 57 (2019/08/20)
Ephrin A2 targeted immunoliposomes incorporating pH-sensitive taxane prodrugs were developed for sustained delivery of active drug to solid tumors. Here we describe the systematic formulation development and characterization of these immunoliposomes. We s
