1150586-64-3

Basic information

• Product Name: CB-86
• Synonyms: CB-86
• CAS NO: 1150586-64-3
• Molecular Formula: C₂₆H₄₃NO₃
• Molecular Weight: 417.62452
• Mol File: 1150586-64-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CB-86(CAS DataBase Reference)
• NIST Chemistry Reference: CB-86(1150586-64-3)
• EPA Substance Registry System: CB-86(1150586-64-3)

Safety Data

• Hazardous Substances Data: 1150586-64-3(Hazardous Substances Data)

Usage

General Description

CB-86 is a synthetic chemical compound that belongs to the class of phenylpropanoids. It is commonly used as a chemical tool to study the activity of the neurotransmitter GABA in the nervous system. CB-86 is a selective antagonist of the GABA receptor, meaning that it blocks the action of GABA at its receptor sites. This makes it a useful tool for studying the effects of GABA in the brain and for understanding the role of GABA receptors in various physiological processes. Additionally, CB-86 has been investigated as a potential treatment for conditions such as anxiety and epilepsy, due to its ability to modulate GABAergic activity in the brain.

Upstream product

• 1150586-50-7 8-[5-(2-methyloctan-2-yl)phenoxy]octanoic acid 
• 765-30-0 Cyclopropylamine 

Relevant articles and documents

New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo

Bearing in mind the pharmacophoric requirements of both (-)-trans-Δ9-tetrahydrocannabinol (THC) and anandamide (AEA), we designed a novel pharmacophore consisting of both a rigid aromatic backbone and a flexible chain with the aim to develop a series of stable and potent ligands of cannabinoid receptors. In this paper we report the synthesis, docking studies, and structure-activity relationships of new resorcinol-anandamide "hybrids" differing in the side chain group. Compounds bearing a 2-methyloctan-2-yl group at position 5 showed a significantly higher affinity for cannabinoid (CB) receptors, in particular when an alkyloxy chain of 7 or 10 carbon atoms was also present at position 1. Derivative 32 was a potent CB 1 and CB2 ligand, with Ki values similar to that of WIN 55-212 and potent antinociceptive activity in vivo. Moreover, derivative 38, although less potent, proved to be the most selective ligand for CB2 receptor (Ki(CB1)) 1 μM, K i(CB2)) 35 nM).