1154750-83-0Relevant articles and documents
A comparative study using conventional methods, ionic liquids, microwave irradiation and combinations thereof for the synthesis of 5-trifluoroacetyl-1,2,3,4-tetrahydropyridines
Andrade, Valquiria P.,Mittersteiner, Mateus,Lobo, Márcio M.,Frizzo, Clarissa P.,Bonacorso, Hélio G.,Martins, Marcos A.P.,Zanatta, Nilo
supporting information, p. 891 - 894 (2018/02/14)
This study reports a comparison between conventional methods, ionic liquids, microwave (MW) irradiation, and combinations thereof for the synthesis of a series of fourteen 1-aryl-2-arylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines. In all of the reactions tested, the products were obtained at very good yields (87–97%), but the reaction times were very different, depending on the method used. Comparing to other methods, the time decreased to 1 min when [BMIM]BF4 under MW irradiation was used, thus evidencing a synergic effect.