115960-14-0

Basic information

• Product Name: Hidiosmin
• Synonyms: 5-O-(beta-Hydroxyethyl)diosmin;4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-Mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-(2-hydroxyethoxy)-2-(3-hydroxy-4-Methoxyphenyl)-;5-(2-hydroxyethoxy)-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[ [(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one;7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-3,5-di-O-hydroxyethyl-2-(3-hydroxy-4-methoxyphenyl)-4H-1-Benzopyran-4-one;7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3'-mono-O-hydroxyethyl-4'-methoxyphenyl)-4H-1-Benzopyran-4-one;O-(beta-Hydroxyethyl)diosmin;Hidiosmin
• CAS NO: 115960-14-0
• Molecular Formula: C30H36O16
• Molecular Weight: 652.59724
• Product Categories: CITRIMORE
• Mol File: 115960-14-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 962.7 °C at 760 mmHg
• Flash Point: 311.1 °C
• Appearance: /
• Density: 1.63±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Methanol (Slightly, Sonicated), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Hidiosmin(CAS DataBase Reference)
• NIST Chemistry Reference: Hidiosmin(115960-14-0)
• EPA Substance Registry System: Hidiosmin(115960-14-0)

Safety Data

• Hazardous Substances Data: 115960-14-0(Hazardous Substances Data)

Usage

Description

Hidiosmin, also known as Hidrosmin, is a semisynthetic drug derived from Diosmin and belongs to the flavonoid family. It is characterized by its yellow to yellow-brown powder form and is recognized for its improved water solubility and bioavailability, which allows for a reduced dosage in comparison to its parent compound, Diosmin. Hidiosmin is known for its effectiveness in treating various venous diseases, particularly Chronic Venous Insufficiency.

Uses

Used in Pharmaceutical Industry:
Hidiosmin is used as a therapeutic agent for the treatment of venous diseases, specifically Chronic Venous Insufficiency. It is more effective than Diosmin in treating edema and varicose ulcers due to its enhanced water solubility and bioavailability, which allows for better absorption by the human body and requires a lower dosage for effective treatment.

InChI:InChI=1/C30H36O16/c1-12-23(34)25(36)27(38)29(43-12)42-11-21-24(35)26(37)28(39)30(46-21)44-14-8-19(41-6-5-31)22-16(33)10-18(45-20(22)9-14)13-3-4-17(40-2)15(32)7-13/h3-4,7-10,12,21,23-32,34-39H,5-6,11H2,1-2H3/t12-,21+,23-,24+,25+,26-,27+,28+,29+,30+/m0/s1

Upstream product

• 75-21-8 oxirane 
• 520-27-4 diosmin 

Relevant articles and documents

Besides sea tune process for the preparation of raw materials

The invention provides a process for preparing a hidrosmin bulk drug. The process comprises the following steps: (1) performing a synthesis reaction; (2) decolorizing a reacting liquid; (3) filtering the decolorizing liquid; (4) crystallizing the filterin