116019-29-5

Basic information

• Product Name: Benzoic acid 2-[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-ylmethoxy]-ethyl ester
• Synonyms: Benzoic acid 2-[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-ylmethoxy]-ethyl ester
• CAS NO: 116019-29-5
• Molecular Weight: 455.454
• Mol File: 116019-29-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid 2-[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-ylmethoxy]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid 2-[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-ylmethoxy]-ethyl ester(116019-29-5)
• EPA Substance Registry System: Benzoic acid 2-[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-ylmethoxy]-ethyl ester(116019-29-5)

Safety Data

• Hazardous Substances Data: 116019-29-5(Hazardous Substances Data)

Upstream product

• 58305-05-8 (2-benzoyloxyethyl)oxymethyl chloride 
• 446-86-6 azathioprine 

Relevant articles and documents

Studies in Nucleosides: Part XVI - Synthesis of Azathioprine Analogues

6--9-(1'-tetrahydrofuranyl)purine (4) , 6--9-(1'-tetrahydropyranyl)purine (5), 9-hydroxyethoxymethyl-6-purine (6), 6--9-(β-D-ribofuranosyl)purine (12), 9-(α-D-arabinofuranosyl)-6-purine (16) and 9-(β-D-2'-deoxyribofuranosyl)-6-purine (11) have been synthesised.Condensation of 1 with dihydrofuran and dihydropyran gives 4 and 5 respectively in excellent yields.The reaction of 1 separately with benzoyloxyethoxymethylene chloride (2), 1-O-acetylribose derivative (7) and 1-chloro-2-deoxyribose derivative (9) and of the chloromercuric complex (13) with 1-bromoarabinose derivative (14) gives the blocked nucleosides (3, 8, 10 and 15) respectively.Deblocking of the nucleosides with methanolic ammonia finally affords 6, 12, 11 and 16 respectively.