1160525-87-0 Usage
Description
P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid AMMoniuM Salt, also known as Fosfomycin (F727500) impurity, is a compound derived from the antibiotic Fosfomycin. It possesses a unique chemical structure that contributes to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid AMMoniuM Salt is used as an impurity in the production of Fosfomycin, an antibiotic with broad-spectrum antibacterial activity. Its presence in the manufacturing process is crucial for ensuring the efficacy and safety of the final product.
Used in Research and Development:
In the field of research and development, P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid AMMoniuM Salt serves as a valuable compound for studying the properties and mechanisms of action of Fosfomycin. This can lead to the discovery of new applications and improvements in the pharmaceutical industry.
Used in Quality Control:
P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid AMMoniuM Salt is also utilized in quality control processes to ensure the purity and potency of Fosfomycin. By monitoring the levels of this impurity, manufacturers can maintain high standards of product quality and comply with regulatory requirements.
Check Digit Verification of cas no
The CAS Registry Mumber 1160525-87-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,5,2 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1160525-87:
(9*1)+(8*1)+(7*6)+(6*0)+(5*5)+(4*2)+(3*5)+(2*8)+(1*7)=130
130 % 10 = 0
So 1160525-87-0 is a valid CAS Registry Number.
1160525-87-0Relevant articles and documents
Studies on the biodegradation of fosfomycin: Synthesis of 13C-labeled intermediates, feeding experiments with rhizobium huakuii PMY1, and Isolation of Labeled Amino Acids from Cell Mass by HPLC
McGrath, John W.,Hammerschmidt, Friedrich,Kaehlig, Hanspeter,Wuggenig, Frank,Lamprecht, Guenther,Quinn, John P.
experimental part, p. 13341 - 13348 (2012/03/22)
Racemic (1R*,2R*)-1,2-dihydroxy-[1-13C 1]propylphosphonic acid and 1-hydroxy-[1-13C 1]acetone were synthesized and fed to R. huakuii PMY1. Alanine and a mixture of valine and methionine were isolated as their N-acetyl derivatives from the cell hydrolysate by reversed-phase HPLC and analyzed by NMR spectroscopy. It was found that the carbon atoms of the respective carboxyl groups were highly 13C-labeled (up to 65 %). Hydroxyacetone is therefore considered an obligatory intermediate of the biodegradation of fosfomycin by R. huakuii PMY1.
