1160556-64-8 Usage
Description
2-Dicyclohexylphosphino-2',6'-bis(diMethylaMino)-1,1'-biphenyl, Min. 98% Cphos, also known as CPhos, is a phosphine ligand with a unique structure that consists of a biphenyl backbone with dicyclohexylphosphino and dimethylamino groups attached to it. 2-Dicyclohexylphosphino-2',6'-bis(diMethylaMino)-1,1'-biphenyl, Min. 98% Cphos is characterized by its high purity (minimum 98%) and is known for its applications in various chemical reactions and processes due to its strong donor properties and steric bulk.
Uses
Used in Pharmaceutical Industry:
CPhos is used as a catalyst in the Pd-catalyzed synthesis of various pharmaceutical compounds, such as 3-cyclopentylindole derivatives, dihydrobenzofurans, and trans-bicyclic sulfamides. Its unique structure and strong donor properties make it an effective catalyst for these reactions, leading to improved yields and selectivity.
Used in Chemical Synthesis:
CPhos is used as a ligand in the Pd-catalyzed Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides. This reaction is an important method for forming carbon-carbon bonds in organic synthesis, and CPhos enhances the efficiency and selectivity of the process.
Used in Catalyst Preparation:
CPhos is used to synthesize palladacycle precatalysts for Negishi coupling of secondary alkylzinc. These precatalysts are essential for facilitating the coupling reaction, and CPhos plays a crucial role in their formation due to its strong donor properties and steric bulk.
Reactions
Preparation of aryl sulfonamides via palladium-catalyzed chlorosulfonylation of arylboronic acids.
Check Digit Verification of cas no
The CAS Registry Mumber 1160556-64-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,0,5,5 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1160556-64:
(9*1)+(8*1)+(7*6)+(6*0)+(5*5)+(4*5)+(3*6)+(2*6)+(1*4)=138
138 % 10 = 8
So 1160556-64-8 is a valid CAS Registry Number.
1160556-64-8Relevant articles and documents
Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides
Han, Chong,Buchwald, Stephen L.
supporting information; experimental part, p. 7532 - 7533 (2009/10/16)
(Chemical Equation Presented) An efficient palladium-catalyzed process has been developed for Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. A palladium catalyst composed of a new biaryldialkylphosphine ligand, CPhos, effectively promotes the rate of the reductive elimination step relative to the rate of the undesired β-hydride elimination. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool forC(sp3)-C(sp2) bond formation.
