116183-81-4

Basic information

• Product Name: (3R)-(-)-3-Aminopyrrolidine dihydrochloride
• Synonyms: 3-PYRROLIDINAMINE, DIHYDROCHLORIDE, (3R)-;(3R)-(-)-3-AMINOPYRROLIDINE DIHYDROCHLORIDE;(R)-PYRROLIDIN-3-YLAMINE DIHYDROCHLORIDE;(R)-PYRROLIDIN-3-AMINE DIHYDROCHLORIDE;PYRROLIDIN-3-YL-AMINE, (R), DIHYDROCHLORIDE;(R)-(-)-3-AMINOPYRROLIDINE DIHYDROCHLORIDE;(R)-3-AMINOPYRROLIDINE DIHYDROCHLORIDE;(R)-(-)-3-AMINOPYRROLIDINE 2HCL
• CAS NO: 116183-81-4
• Molecular Formula: C₄H₁₀N₂*2ClH
• Molecular Weight: 159.06
• EINECS: -0
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline;Benzenes;3-Aminopyrrolidines;Amines (Chiral);Chiral 3-Aminopyrrolidines;Chiral Building Blocks;Synthetic Organic Chemistry
• Mol File: 116183-81-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 283°C (dec.)
• Boiling Point: 214.5 °C at 760 mmHg
• Flash Point: 83.5 °C
• Appearance: White to off-white/Powder
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: -1.1 ° (C=10, H2O)
• Storage Temp.: Room temperature.
• Water Solubility: very faint turbidity
• Sensitive: Hygroscopic
• BRN: 5852700
• CAS DataBase Reference: (3R)-(-)-3-Aminopyrrolidine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-(-)-3-Aminopyrrolidine dihydrochloride(116183-81-4)
• EPA Substance Registry System: (3R)-(-)-3-Aminopyrrolidine dihydrochloride(116183-81-4)

Safety Data

• Hazard Codes: C,Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 116183-81-4(Hazardous Substances Data)

Usage

General Description

(3R)-(-)-3-Aminopyrrolidine Dihydrochloride is a chemical compound that belongs to the class of amines. It is a dihydrochloride salt of (3R)-(-)-3-aminopyrrolidine and is commonly used in the pharmaceutical industry. (3R)-(-)-3-Aminopyrrolidine Dihydrochloride has a 3R stereochemistry, meaning the three substituents attached to the nitrogen atom are arranged in a counterclockwise direction. It has a wide range of applications, including as an intermediate in the synthesis of pharmaceuticals and as a chiral auxiliary in organic chemistry. Additionally, it has been studied for its potential use in the treatment of certain medical conditions and as a building block for the synthesis of other complex molecules.

InChI:InChI=1/C4H10N2.2ClH/c5-4-1-2-6-3-4;;/h4,6H,1-3,5H2;2*1H/t4-;;/m1../s1

Upstream product

• 116183-82-5 (R)-pyrrolidin-3-amine 
• 116143-03-4 (3R)-3-azido-1-(phenylmethyl)pyrrolidine 
• 114636-29-2 (3S)-3-azido-1-(phenylmethyl)pyrrolidine 

Downstream Products

• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 181625-29-6 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid triethylamine salt 
• 816424-31-4 2-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-3-[(2,4-difluorophenyl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one 
• 956467-63-3 N-((3R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-3-pyrrolidinyl)-3,4-bis(methyloxy)benzenesulfonamide 
• 132195-60-9 7-((S)-3-Amino-pyrrolidin-1-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 132195-48-3 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Process for producing 1H-3-aminopyrrolidine and derivatives thereof

A process for producing 1H-3-aminopyrrolidine and derivatives thereof is disclosed. The process is especially useful for producing optically active 1H-3-aminopyrrolidine and derivatives thereof and in this case comprises reacting an optically active amino-protected aspartic anhydride represented by the formula (1) with a primary amine represented by the formula R'NH2, subjecting the reaction product to cyclodehydration to obtain an optically active 1-aralkyl-3-(protected amino)pyrrolidine-2,5-dione compound represented by the formula (2), subsequently eliminating the protective group from the 3-position amino group of the compound represented by the formula (2) to obtain an optically active 1-aralkyl-3-aminopyrrolidine-2,5-dione compound represented by the formula (3), reducing the carbonyl groups of the compound represented by the formula (3) to obtain either an optically active 1-aralkyl-3-aminopyrrolidine compound represented by the formula (4) or a salt thereof with a protonic acid, and then subjecting the compound represented by the formula (4) or the salt thereof to hydrogenolysis to obtain an optically active 1H-3-aminopyrrolidine or a protonic acid salt thereof.

1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents

There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine- and quinoline-carboxylic acids.