1162-82-9

Basic information

• Product Name: GENISTEIN TRIMETHYL ETHER
• Synonyms: 4',5,7-TRIMETHOXYISOFLAVONE;5,7-O-DIMETHYLBIOCHANIN A;5,7,4'-TRIMETHOXYISOFLAVONE;GENISTEIN TRIMETHYL ETHER;5,7-O-Dimethylbiochanin A Genistein trimethyl ether;5,7-dimethoxy-3-(4-methoxyphenyl)chromen-4-one;5,7-dimethoxy-3-(4-methoxyphenyl)chromone
• CAS NO: 1162-82-9
• Molecular Formula: C₁₈H₁₆O₅
• Molecular Weight: 312.32
• Mol File: 1162-82-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 506.5°Cat760mmHg
• Flash Point: 225.5°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 2.21E-10mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: GENISTEIN TRIMETHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: GENISTEIN TRIMETHYL ETHER(1162-82-9)
• EPA Substance Registry System: GENISTEIN TRIMETHYL ETHER(1162-82-9)

Safety Data

• Hazardous Substances Data: 1162-82-9(Hazardous Substances Data)

Usage

General Description

Genistein trimethyl ether is a chemical compound that belongs to the class of isoflavones, which are found in soy products and other legumes. It is a derivative of genistein, a naturally occurring compound with antioxidant and anticancer properties. Genistein trimethyl ether has been studied for its potential health benefits, including its ability to inhibit the growth of cancer cells and its potential as a treatment for certain types of cancer. Additionally, it has been found to have anti-inflammatory and anti-angiogenic properties, making it a promising compound for potential therapeutic applications. Research on genistein trimethyl ether is ongoing, with a focus on its potential use in cancer treatment and its effects on various biological pathways.

InChI:InChI=1/C18H16O5/c1-20-12-6-4-11(5-7-12)14-10-23-16-9-13(21-2)8-15(22-3)17(16)18(14)19/h4-10H,1-3H3

Upstream product

• 446-72-0 5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on 
• 77-78-1 dimethyl sulfate 
• 491-80-5 5,7-Dihydroxy-3-(4-methoxy-phenyl)-chromen-4-on 
• 552-59-0 prunetin 
• 74-88-4 methyl iodide 
• 4569-98-6 7-hydroxy-3-(4-hydroxy-phenyl)-5-methoxy-chromen-4-one 
• 500-99-2 3,5-dimethoxyphenol 
• 3420-72-2 flavokawain A 
• 153488-88-1 3-allyloxycarbonyl-5,7-dimethoxychroman-4-one 
• 18649-43-9 4-methoxyphenyllead(IV) triacetate 
• 54107-66-3 5,7-dimethoxy-4-chromanone 
• 3420-72-2 2'-hydroxy-4,4',6'-trimethoxychalcone 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 66074-95-1 4',5,7-trimethoxyflavanone 

Downstream Products

• 68939-22-0 7-hydroxy-5-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 552-59-0 prunetin 
• 34086-51-6 4',7-dimethoxy-5-hydroxyisoflavone 
• 21554-70-1 4',5,7-trimethoxyisoflavanone 
• 1179998-22-1 2-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-pyrimido[1,2-a]benzimidazole 
• 1380484-11-6 8-carbamoyl-4-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)imidazo[1,5-a]pyrimidine 
• 1456626-62-2 3-cyano-6-(2-hydroxy-4,6-dimethoxyphenyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one 

Relevant articles and documents

Isoflavones as potentiators of antibacterial activity

Isoflavones isolated from Lupinus argenteus were found to potentiate the antibacterial activity of α-linolenic acid, also found in the same plant. The isoflavones also potentiated the activity of the natural plant antibiotic berberine and the synthetic fluoroquinoline antibiotic norfloxacin. The isoflavones increased the uptake of berberine into Staphylococcus aureus cells, indicating that they may be inhibiting a multidrug resistance pump (MDR). Thus, L. argenteus contains a weak antibacterial and also MDR pump inhibitors, which increase its potency.

First Total Synthesis and Cytotoxicity of Naturally Occurring Lespedezol E1

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Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans

Diversity-oriented synthesis of derivatives of natural products is an important approach for the discovery of novel drugs. In this paper, a series of novel 3,4-diaryl-1H-pyrazoles and 3,5-diaryl-1H-pyrazoles derivatives were synthesized through the one-po

Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein

A series of deoxybenzoin derivatives from genistein were synthesized and their structures were elucidated by 1H NMR, mass spectral data and micro analyses. The structures of 2, 7 and 10 were determined by single-crystal X-ray analysis. These obtained compounds were evaluated for their assayed antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Most compounds have displayed comparable antibacterial activity against bacterial. On the basis of the biological results, structure-activity relationships are discussed.