116247-98-4Relevant articles and documents
Effect of through-bond interaction on conformation and structure in rod-shaped donor - acceptor systems: Part 1. Crystal structures of five N-arylpiperidin-4-one derivatives
De Ridder, Dirk J. A.,Goubitz, Kees,Schenk, Henk,Krijnen, Bert,Verhoeven, Jan W.
, p. 799 - 811 (2003)
The crystal structures of five N-arylpiperidin-4-one derivatives 2P2, 3P2, 5P2, 1P3, and 2P3 are presented (Fig. 2 and Tables 1-5) and discussed together with the derivatives 1P2 and 4P2 published previously. In all but one structure, 1P2, the aryl group is in an equatorial position. The piperidine ring adopts a normal chair conformation. In 1P2, the piperidine ring central C-C bonds are significantly elongated, which is consistent with the idea that through-bond interaction is more pronounced in the axial conformation. Through-bond interaction also influences the pyramidalization at the piperidine C(4)-atom in such a way that a strong interaction is directing the ethylene C-atom C(9) into the axial direction.
5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND
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Page/Page column 25, (2011/05/16)
The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: [wherein, R1 represents a group —X-Q1, X-Q1-Y-Q2 or X-Q1-Y-Q2-Z-Q3, X represents a single bond, —CH2— or the like, Q1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, —CH2—, or the like, Q2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, —CR11R12— or the like, R11 and R12 each independently represents a hydrogen atom, a halogen atom or the like, Q3 represents a phenyl group which may have substituent(s), a C3-C7 cycloalkyl group which may have substituent(s), a C3-C7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R2 represents a C1-C3 alkyl group or the like, and R3 represents a hydrogen atom or a methyl group].
Synthesis and exploratory photophysical investigation of donor-bridge-acceptor systems derived from N-substituted 4-piperidones
Scherer, T.,Hielkema, W.,Krijnen, B.,Hermant, R. M.,Eijckelhoff, C.,et al.
, p. 535 - 548 (2007/10/02)
We report a two-step synthesis for N-aryl- and N-alkyl-substituted 4-piperidones, in which the N substituent can easily be varied.A number of intramolecular donor-acceptor systems was synthesized from these piperidones by conversion of the carbonyl functionality.The influence of the N-aryl donor on the electronic absorption and fluorescence spectra was investigated systematically.It was concluded that some systems can be used as efficient fluorescent probes with a high sensitivity for solvent polarity.