116355-84-1 Usage
Description
Fumonisin B2 (FB2) is a potent mycotoxin and a diester of tricarballylic acid and polyhydric alcohols. It belongs to the family of toxins known as fumonisins, primarily produced by Fusarium verticillioides and Fusarium moniliforme molds. FB2 is a structural analog of fumonisin B1, with a pale yellow crystalline solid appearance. It is more cytotoxic than fumonisin B1 and inhibits sphinganine-N-acetyltransferase (ceramide synthase), playing a role as a carcinogenic agent and an Aspergillus metabolite.
Uses
Used in Agricultural Industry:
Fumonisin B2 is used as a contact herbicide for producing desiccation and defoliation, aiding in the control of unwanted plant growth.
Used in Pharmaceutical Research:
Fumonisin B2 acts as an inhibitor of sphingosine N-acyltransferase, blocking the formation of ceramide from sphingosine. This property makes it a subject of interest in the study of ceramide biosynthesis and its potential applications in pharmaceutical research, particularly in the development of treatments for various diseases.
Used in Mycotoxin Research:
As a minor analogue of a family of potent mycotoxins, Fumonisin B2 is used in research to better understand the pharmacology of the fumonisins, with a focus on its effects on ceramide biosynthesis and its potential implications in animal toxicity and carcinogenicity.
Biochem/physiol Actions
Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.
Safety Profile
Fumonisin B2, a mycotoxin produced by Fusariummoniliforme in a variety of cereals, is a potent inhibitor of sphingosine N-acyltransferase (ceramidesynthase), blocking sphingolipid de novo synthesis. Fumonisin (FB) is a mycotoxin, a structurally similar bidentate compound composed of different polyhydric alcohols and propionic tricarboxylic acids, of which fumonisin B1 (FB1), fumonisin B2 (FB2) and fumonisin B3 (FB3) are the main components of contaminated food and its products, and a potential trigger for cancer, and has been declared by the International Agency for Research on Cancer as The International Agency for Research on Cancer has declared fumonisins as "Class 2B" toxicants (possible carcinogens to humans).
Check Digit Verification of cas no
The CAS Registry Mumber 116355-84-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,3,5 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 116355-84:
(8*1)+(7*1)+(6*6)+(5*3)+(4*5)+(3*5)+(2*8)+(1*4)=121
121 % 10 = 1
So 116355-84-1 is a valid CAS Registry Number.
InChI:InChI=1/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47)/t20-,21+,22-,23+,24+,25+,26-,27-,32+/m0/s1
