116457-99-9 Usage
Description
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.
references
[1] yu l, deems r a, hajdu j, et al. the interaction of phospholipase a2 with phospholipid analogues and inhibitors[j]. journal of biological chemistry, 1990, 265(5): 2657-2664.[2] balsinde j, balboa m a, insel p a, et al. regulation and inhibition of phospholipase a2[j]. annual review of pharmacology and toxicology, 1999, 39(1): 175-189.[3] mallat z, lambeau g, tedgui a. lipoprotein-associated and secreted phospholipases a2 in cardiovascular disease[j]. circulation, 2010, 122(21): 2183-2200.
Check Digit Verification of cas no
The CAS Registry Mumber 116457-99-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,4,5 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 116457-99:
(8*1)+(7*1)+(6*6)+(5*4)+(4*5)+(3*7)+(2*9)+(1*9)=139
139 % 10 = 9
So 116457-99-9 is a valid CAS Registry Number.
116457-99-9Relevant articles and documents
A NEW APPROACH TO THE SYNTHESIS OF THIOETHER PHOSPHOLIPIDS. PREPARATION OF 1-THIOHEXADECYL-2-N-ACYLAMINODEOXYGLYCEROPHOSPHOCHOLINES
Bhatia, Suresh K.,Hajdu, Joseph
, p. 31 - 34 (2007/10/02)
A novel stereospecific route to biologically active thioester phospholipids is reported.
