1166228-30-3 Usage
Description
3-Fluoro-4-desfluoro BicalutaMide is a chemical compound derived from Bicalutamide, which is a non-steroidal peripherally active antiandrogen. It is characterized by the presence of a fluorine atom at the 3rd position and the absence of a fluorine atom at the 4th position in its molecular structure. This modification in the molecular structure may result in different pharmacological properties compared to its parent compound, Bicalutamide.
Uses
Used in Pharmaceutical Industry:
3-Fluoro-4-desfluoro BicalutaMide is used as an antiandrogen for the treatment of androgen-dependent conditions such as prostate cancer. It functions by competitively inhibiting the binding of androgens to androgen receptors, thereby reducing the growth and proliferation of androgen-sensitive tumor cells.
Additionally, 3-Fluoro-4-desfluoro BicalutaMide is used as an antineoplastic agent, specifically in the hormonal treatment of certain types of cancer. Its mechanism of action involves disrupting the hormonal balance within the body, which can help slow down or halt the growth of hormone-dependent tumors.
Check Digit Verification of cas no
The CAS Registry Mumber 1166228-30-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,6,2,2 and 8 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1166228-30:
(9*1)+(8*1)+(7*6)+(6*6)+(5*2)+(4*2)+(3*8)+(2*3)+(1*0)=143
143 % 10 = 3
So 1166228-30-3 is a valid CAS Registry Number.
1166228-30-3Relevant articles and documents
Synthesis of potential impurities of bicalutamide
Bhise, Nandu Baban,Sathe, Dhananjay Govind,Radhakrishanan, Tarur,Deore, Raviraj
experimental part, p. 1516 - 1526 (2009/10/17)
Bicalutamide is an oral nonsteroidal, anti-androgen drug used for prostate cancer. It binds to the androgen receptor. During the bulk synthesis of bicalutamide, various impurities are formed. The present work details the development of simple processes for the preparation of impurities of bicalutamide, viz bical-sulfoxides (6), bical-deshydroxy (10), bical-desfluoro (10a), bical-2-fluoro (10b), and bical-3-fluoro (10c). Copyright Taylor & Francis Group, LLC.
