116818-62-3

Basic information

• Product Name: Piperazine, 1-(1-aziridinylcarbonyl)-4-methyl- (9CI)
• Synonyms: Piperazine, 1-(1-aziridinylcarbonyl)-4-methyl- (9CI);1-(AZIRIDIN-1-YLCARBONYL)-4-METHYLPIPERAZINE
• CAS NO: 116818-62-3
• Molecular Formula: C8H15N3O
• Molecular Weight: 169.2242
• Product Categories: PIPERIDINE
• Mol File: 116818-62-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 1-(1-aziridinylcarbonyl)-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(1-aziridinylcarbonyl)-4-methyl- (9CI)(116818-62-3)
• EPA Substance Registry System: Piperazine, 1-(1-aziridinylcarbonyl)-4-methyl- (9CI)(116818-62-3)

Safety Data

• Hazardous Substances Data: 116818-62-3(Hazardous Substances Data)

Upstream product

• 151-56-4 ethyleneimine 
• 55112-42-0 4-methylpiperazine-1-carbonyl chloride monohydrochloride 
• 109-01-3 1-methyl-piperazine 

Relevant articles and documents

Studies in Potential Filaricides: Part 19 - Synthesis of 1-Methyl-4-substituted Carbonylpiperazines as Diethylcarbamazine Analogs

The synthesis and antifilarial activity of a series of 1-methyl-4-substituted carbamoyl- and carbonylpiperazines (6 - 42) against Litomosoides carinii in cotton rats and Dipetalonema viteae in Mastomys natalensis are described.The most potent compound of this series, 1-methyl-4-(pyrrolidin-1-yl)carbonylpiperazine (7) causes 95 - 98 percent reduction of blood microfilarial count in cotton rats infected with L. carinii at an intraperitoneal or oral dose of 1.5 (base) or 3 (citrate) mg/kg given for 6 days.A number of other compounds also exhibit marked microfilaricidal efffect in the dose range of 6 - 30 mg/kg.