1169-79-5

Basic information

• Product Name: quinestradol
• Synonyms: 3-cyclopentyloxyoestra-1,3,5(10)-triene-16-alpha,17-beta-diol;quinestradol;Colpovis;Pentovis;Quinestradiol;(16R,17R)-3-(cyclopentoxy)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-16,17-diol;(16R,17R)-3-cyclopentyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-16,17-diol
• CAS NO: 1169-79-5
• Molecular Formula: C₂₃H₃₂O₃
• Molecular Weight: 356.49838
• EINECS: 214-623-2
• Mol File: 1169-79-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 98-100°
• Boiling Point: 510.2 °C at 760 mmHg
• Flash Point: 262.3 °C
• Appearance: /
• Density: 1.188 g/cm³
• Vapor Pressure: 3.12E-11mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: quinestradol(CAS DataBase Reference)
• NIST Chemistry Reference: quinestradol(1169-79-5)
• EPA Substance Registry System: quinestradol(1169-79-5)

Safety Data

• Hazardous Substances Data: 1169-79-5(Hazardous Substances Data)

Usage

General Description

Quinestradol is a synthetic estrogen that belongs to the family of estradiol derivatives. It is commonly used as a key ingredient in hormone replacement therapy to alleviate symptoms of menopause, such as hot flashes, vaginal dryness, and mood swings. Quinestradol works by mimicking the natural estrogen hormone in the body, thereby providing relief from the symptoms associated with estrogen deficiency. However, it is important to use quinestradol under the guidance of a healthcare professional as it may have potential side effects and risks, especially when used in combination with other medications. Overall, quinestradol plays a crucial role in managing menopausal symptoms and improving the quality of life for women experiencing estrogen deficiency.

InChI:InChI=1/C23H32O3/c1-23-11-10-18-17-9-7-16(26-15-4-2-3-5-15)12-14(17)6-8-19(18)20(23)13-21(24)22(23)25/h7,9,12,15,18-22,24-25H,2-6,8,10-11,13H2,1H3/t18?,19?,20?,21-,22+,23?/m1/s1

Upstream product

• 137-43-9 Cyclopentyl bromide 
• 50-27-1 Estriol 
• 7732-18-5 water 
• 510-64-5 19-hydroxy-4-androstene-3,17-dione 
• 95282-98-7 19-acetoxyandrosta-1,4-diene-3,17-dione 
• 95436-36-5 (8R,9S,13S,14S,16R)-16-Bromo-3-cyclopentyloxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one 
• 1852-81-9 estrone 3-cyclopentyl ether 

Relevant articles and documents

Eco-friendly synthesis of 3-etherified estrones

The conventional etherification uses toxic or hardly degradable alkylating agents. An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3-secondary ethers from easily available dienone 1. Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material.