1169861-36-2

Basic information

• Product Name: 2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-benzamidrazone
• Synonyms: 2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-benzamidrazone
• CAS NO: 1169861-36-2
• Molecular Weight: 355.461
• Mol File: 1169861-36-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-benzamidrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-benzamidrazone(1169861-36-2)
• EPA Substance Registry System: 2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-benzamidrazone(1169861-36-2)

Safety Data

• Hazardous Substances Data: 1169861-36-2(Hazardous Substances Data)

Upstream product

• 1169861-33-9 2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-benzamide 
• 938-73-8 2-ethoxybenzamide 
• 5308-25-8 4-ethylpiperazine 
• 383427-93-8 2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-benzamidine 

Downstream Products

• 1169861-31-7 N-[1-[3-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-phenyl]-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl]-butanamide 
• 224785-90-4 vardenafil 

Relevant articles and documents

N-BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF

Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure.

An improved synthetic route for preparative process of vardenafil

A new, convergent synthetic route for the process optimization of vardenafil (Levitra), a potent and effective PDE5 inhibitor, is described. Key improved steps in the preparative process are that the chlorosulfonation reaction is at the beginning and the dehydration-cyclisation reaction is at a later stage so that the synthetic route has a better overall yield and simpler workup operations. The yield of vardenafil produced from this synthetic route is around 45% over seven steps with purity at 99.2% (HPLC).