1171117-75-1Relevant articles and documents
Convenient asymmetric synthesis of both enantiomers of 3,4-disubstituted 3,4-dihydro-1,4-benzoxazin-2-ones
Youk, Eunjee,Park, Wongi,Park, Yong Sun
, p. 1331 - 1337 (2018)
Both enantiomers of N-substituted 3-arylated 3,4-dihydro-1,4-benzoxazin-2-ones were conveniently synthesized up to 93:7 er based on the dynamic kinetic resolution of either (R)-pantolactone- or l-mandelate-derived α-bromo arylacetates in nucleophilic subs
Catalytic Enantioselective Access to Dihydroquinoxalinones via Formal α-Halo Acyl Halide Synthon in One Pot
Crescenzi, Carlo,Lattanzi, Alessandra,Mancinelli, Michele,Mazzanti, Andrea,Meninno, Sara,Volpe, Chiara
supporting information, p. 23819 - 23826 (2021/10/04)
An enantioselective one-pot catalytic strategy to dihydroquinoxalinones, featuring novel 1-phenylsulfonyl-1-cyano enantioenriched epoxides as masked α-halo acyl halide synthons, followed by a domino ring-opening cyclization (DROC), is documented. A popula
Biomimetic Hydrogenation Catalyzed by a Manganese Model of [Fe]-Hydrogenase
Hu, Xile,Pan, Hui-Jie
supporting information, p. 4942 - 4946 (2020/02/11)
[Fe]-hydrogenase is an efficient biological hydrogenation catalyst. Despite intense research, Fe complexes mimicking the active site of [Fe]-hydrogenase have not achieved turnovers in hydrogenation reactions. Herein, we describe the design and development of a manganese(I) mimic of [Fe]-hydrogenase. This complex exhibits the highest activity and broadest scope in catalytic hydrogenation among known mimics. Thanks to its biomimetic nature, the complex exhibits unique activity in the hydrogenation of compounds analogous to methenyl-H4MPT+, the natural substrate of [Fe]-hydrogenase. This activity enables asymmetric relay hydrogenation of benzoxazinones and benzoxazines, involving the hydrogenation of a chiral hydride transfer agent using our catalyst coupled to Lewis acid-catalyzed hydride transfer from this agent to the substrates.