1173922-30-9

Basic information

• Product Name: 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol
• Synonyms: 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol
• CAS NO: 1173922-30-9
• Molecular Weight: 248.13
• Mol File: 1173922-30-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol(1173922-30-9)
• EPA Substance Registry System: 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol(1173922-30-9)

Safety Data

• Hazardous Substances Data: 1173922-30-9(Hazardous Substances Data)

Usage

General Description

1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol is a chemical compound that is commonly used in organic synthesis and medicinal chemistry. It contains a boron atom and a phenyl group, making it useful as a reagent in the formation of carbon-carbon and carbon-heteroatom bonds. The tetramethyl-1,3,2-dioxaborolan-2-yl group is a boronic ester that is widely used in Suzuki-Miyaura cross-coupling reactions for the construction of biaryl compounds. The compound also has potential applications in the development of new pharmaceuticals and agrochemicals due to its versatile reactivity and ability to introduce functional groups into organic molecules. Overall, 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol is a valuable building block in chemical synthesis and drug discovery.

Upstream product

• 149104-90-5 4-acetylphenylboronic acid 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 73183-34-3 bis(pinacol)diborane 
• 99-90-1 para-bromoacetophenone 
• 171364-81-1 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 

Downstream Products

• 1173922-36-5 (S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 
• 1351956-00-7 (R)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 
• 1173922-42-3 (R)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl acetate 
• 3562-73-0 1-(4-phenyl-phenyl)-1-ethanol 
• 1404094-93-4 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylchloroformate 
• 149104-90-5 4-acetylphenylboronic acid 
• 171364-81-1 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 
• 1173922-51-4 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl acetate 

Relevant articles and documents

Organic fluorescent sensing material capable of selectively detecting nerve agent, and preparation method and application thereof

The invention belongs to the field of organic semiconductor nanomaterials, and concretely relates to an organic fluorescent sensing material capable of selectively detecting a nerve agent, and a preparation method and application thereof. The invention prepares the organic fluorescent sensing material capable of selectively detecting the nerve agent. A series of P type organic fluorescent sensing materials based on carbazole molecules synthesize to form a structure of a carbazole derivative with different side chains through changing side chains of the carbazole molecules and a polymerization degree thereof, and a one-dimensional organic semiconductor nanowire is obtained through a self-assembly method, namely the organic fluorescent sensing material capable of selectively detecting the nerve agent. The nanowire provided by the invention has the characteristics of large specific surface area, more surface porosity and the like, the nerve agent to be detected is favorably adsorbed and diffused on the surface of the nanowire, and a detection limit is greatly reduced. Therefore, the organic fluorescent sensing material provided by the invention can be used as a fluorescence sensor with an excellent performance capable of recognizing the nerve agent.

Application of a promiscuous Arthrobacter sp. from Antarctic in aerobic (R)-selective deracemization and anaerobic (S)-selective reduction

Inspired by enzyme-catalyzed reactions with microorganisms found in harsh marine environments, in which the amount of oxygen is restrict, we have shown that Arthrobacter sp. can perform different chemical transformations by switching from anaerobic to aerobic reaction conditions. Depending on the presence or absence of oxygen, either alcohol deracemization or ketone reduction with enantiocomplementary selectivities can be performed by the same microorganism. For example, reactions performed in the presence of oxygen favored the deracemization process, in which a racemic mixture of 1-(4-methylphenyl)ethanol was enriched to the (R)-alcohol in high conversion (94%) and high enantiomeric excess (94%). On the other hand, reaction in the absence of oxygen favored the reduction process, in which 4-methyl-acetophenone was converted to the (S)-alcohol in good conversion (58%) and excellent enantiomeric excess (>99%). These concepts were applied for both deracemization and enantioselective reduction of heteroatom-containing (silicon, phosphorus, tin and boron) molecules. Moreover, preparative scale reactions were also performed for both chemical processes.

Lipase-catalyzed highly enantioselective kinetic resolution of boron-containing chiral alcohols

The first application of enzymes as catalysts to obtain optically pure boron compounds is described. The kinetic resolution of boron-containing chiral alcohols via enantioselective transesterification catalyzed by lipases was studied. Aromatic, allylic, and aliphatic secondary alcohols containing a boronate ester or boronic acid group were resolved by lipase from Candida antartica (CALB), and excellent E values (E > 200) and high enantiomeric excesses (up to >99%) of both remaining substrates and acetylated product were obtained.