1174046-84-4

Basic information

• Product Name: Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
• Synonyms: Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate;3-Pyridinecarboxylic acid, 4-ethoxy-1,2-dihydro-2-oxo-, ethyl ester
• CAS NO: 1174046-84-4
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211
• Mol File: 1174046-84-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 424.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.29±0.10(Predicted)
• CAS DataBase Reference: Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate(1174046-84-4)
• EPA Substance Registry System: Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate(1174046-84-4)

Safety Data

• Hazardous Substances Data: 1174046-84-4(Hazardous Substances Data)

Usage

General Description

Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate is a chemical compound with the molecular formula C11H15NO4. It is a derivative of pyridine and belongs to the dihydropyridine class of compounds. This chemical is commonly used in pharmaceutical research and development, particularly for its potential in drug discovery and medicinal chemistry. It has shown promising biological activities such as antihypertensive, antioxidant, and calcium channel blocking properties, making it a target for the synthesis of new drugs. Additionally, this compound has been explored for its potential applications in the treatment of cardiovascular diseases and other related medical conditions. Overall, Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate is an important chemical with potential therapeutic benefits.

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Downstream Products

• 1174046-87-7 4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid ethyl ester 
• 1174046-90-2 4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid 
• 1345855-09-5 4-ethoxy-1-(4-fluoro-phenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride 
• 1345855-10-8 N-(2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-12-0 N-(5-chloro-2-fluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-15-3 N-(4-(2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-16-4 N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-17-5 N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-18-6 N-(4-(3-(1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1439877-68-5 N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1439877-40-3 N-(4-((2-acetamidopyridin-4-yl)oxy)-5-chloro-2-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 

Relevant articles and documents

BIOMARKER-BASED THERAPEUTIC COMPOSITION

The present invention provides an anticancer agent for treating a patient who is resistant to a protein kinase inhibitor, the anticancer agent comprising, as an active ingredient, a thienopyridine derivative compound or a pharmaceutically acceptable salt thereof. Here, the patient may be a patient carrying active RON. In addition, the patient may be a patient carrying normal KRAS. In addition, the anticancer agent may be applied to a patient who is resistant to an EGFR inhibitor. In particular, the anticancer agent may be usefully used to treat a patient who is resistant to the therapeutic agent cetuximab.

HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF

Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Since a thienopyridine derivative compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof of the present invention has an excellent effect of inhibiting protein kinase activity, a pharmaceutical composition comprising the same can be usefully used for preventing or treating diseases related to protein kinase activity.COPYRIGHT KIPO 2020