117685-21-9Relevant articles and documents
Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives
Zou, Hong-Bin,Zhang, Liang,Yang, Lei-Xiang,Yang, Liu-Qing,Zhao, Yu,Yu, Yong-Ping,Stoeckigt, Joachim
experimental part, p. 203 - 221 (2011/04/15)
Three series of di- and trisubstituted derivatives of cinnamic alcohol and its conjugated dienol analogues were designed and synthesised. The derivatives were screened for cytotoxicity against nine tumour cell lines: KB, A549, Hela, CNE, PC-3, BEL-7404, HL-60, BGC823 and P388D1. Most of the cinnamic alcohol derivatives showed cytotoxic activity. The compound 7-(4',5'-dichlorobenzyloxy)- 6,8-dihydroxycinnamic alcohol (55) exhibited significant cytotoxicity to seven human tumour cell lines on a micromolar range, especially with regard to the KB and P388D1 cell lines, showing IC50 values of 0.4 and 0.5μ M, respectively. The structure-activity relationships of the derivatives are discussed.
Coniferin and derivatives: A fast and easy synthesis via the aldehyde series using phase-transfer catalysis
Daubresse, Nicolas,Francesch, Charlette,Mhamdi, Farida,Rolando, Christian
, p. 157 - 161 (2007/10/03)
Coniferin was synthesised in good yields (56% starting from vanillin) under mild conditions. A one-pot coupling of the glucosidation and Wittig- type reactions led to coniferaldehyde tetra-O-acetylglucoside, easily reduced into tetra-O-acetylconiferin by sodium borohydride. Similar procedures were used for the synthesis of syringin and the glucoside of 4-coumaryl alcohol.