1178094-73-9

Basic information

• Product Name: (Z)-6-methoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one
• Synonyms: (Z)-6-methoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one
• CAS NO: 1178094-73-9
• Molecular Weight: 253.257
• Mol File: 1178094-73-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-6-methoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-6-methoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one(1178094-73-9)
• EPA Substance Registry System: (Z)-6-methoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one(1178094-73-9)

Safety Data

• Hazardous Substances Data: 1178094-73-9(Hazardous Substances Data)

Upstream product

• 6272-26-0 6-hydroxybenzofuran-3-one 

Downstream Products

• 1250364-25-0 (Z)-1-benzyl-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium bromide 
• 1250364-32-9 (Z)-1-(2-methylbenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-28-3 (Z)-1-(2-fluorobenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-37-4 (Z)-1-(4-methylbenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 
• 1250364-31-8 (Z)-1-(4-fluorobenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium bromide 
• 1250364-30-7 (Z)-1-(3-fluorobenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride 

Relevant articles and documents

Blood-brain barrier permeable anticholinesterase aurones: Synthesis, structure-activity relationship, and drug-like properties

A series of novel aurones bearing amine and carbamate functionalities at various positions (rings A and/or B) of the scaffold was synthesized and evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activities. Structure-activity relationship study disclosed several potent submicromolar acetylcholinesterase inhibitors (AChEIs) particularly aurones bearing piperidine and pyrrolidine moieties at ring A or ring B. Bulky groups particularly methoxyls, and carbamate to a lesser extent, at either rings were also prominently featured in these AChEI aurones as exemplified by the trimethoxyaurone 4-3. The active aurones exhibited a lower butyrylcholinesterase inhibition. A 3g€2-chloroaurone 6-3 originally designed to improve the metabolic stability of the scaffold was the most potent of the series. Molecular docking simulations showed these AChEI aurones to adopt favourable binding modes within the active site gorge of the Torpedo californica AChE (TcAChE) including an unusual chlorine-π interaction by the chlorine of 6-3 to establish additional bondings to hydrophobic residues of TcAChE. Evaluation of the potent aurones for their blood-brain barrier (BBB) permeability and metabolic stability using PAMPA-BBB assay and in vitro rat liver microsomes (RLM) identified 4-3 as an aurone with an optimal combination of high passive BBB permeability and moderate CYP450 metabolic stability. LC-MS identification of a mono-hydroxylated metabolite found in the RLM incubation of 4-3 provided an impetus for further improvement of the compound. Thus, 4-3, discovered within this present series is a promising, drug-like lead for the development of the aurones as potential multipotent agents for Alzheimer's disease.