117918-58-8 Usage
Chemical structure
A heterocyclic compound consisting of a pyrrolidine ring with a carbonyl group attached to the thiophene ring at the 1 position and a carboxylic acid group attached to the pyrrolidine ring at the 2 position.
Classification
Belongs to the class of organic compounds known as heteroaromatic compounds.
Applications
Commonly used in organic synthesis and medicinal chemistry.
Potential uses
May have potential applications in pharmaceutical research and drug development due to its structural features.
Synthesis utility
Can be used as a building block for the synthesis of biologically active molecules.
Functional groups
Contains a thiophene ring, a carbonyl group, a pyrrolidine ring, and a carboxylic acid group.
Reactivity
The presence of the carbonyl and carboxylic acid groups may allow for various chemical reactions, such as nucleophilic addition, esterification, and amide formation.
Structural features
The presence of both a thiophene ring and a pyrrolidine ring in the molecule contributes to its unique properties and potential applications in medicinal chemistry and pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 117918-58-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,9,1 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 117918-58:
(8*1)+(7*1)+(6*7)+(5*9)+(4*1)+(3*8)+(2*5)+(1*8)=148
148 % 10 = 8
So 117918-58-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO3S/c12-9(8-4-2-6-15-8)11-5-1-3-7(11)10(13)14/h2,4,6-7H,1,3,5H2,(H,13,14)/p-1/t7-/m0/s1
117918-58-8Relevant articles and documents
Synthesis and Evaluation of Antileukemic Activity of 5-Thienyl- or 5-(2-Furyl)-2,3-dihydro-6,7-bis(hydroxymethyl)-1H-pyrrolizine Bis(alkylcarbamates) and Derivates
Laduree, Daniel,Lancelot, Jean-Charles,Robba, Max,Chenu, E.,Mathe, G.
, p. 456 - 461 (1989)
Treatment of N-(2-furoyl)proline (1a) or N-thenoylprolines (1b, 1c) and N-(2-thenoyl)thiazolidine-4-carboxylic acid (1d) with acetic anhydride and dimethyl acetylenedicarboxylate gave 5-substituted derivatives of dimethyl 2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate (2a, 2b, 2c) and derivatives of dimethyl 5-(2-thienyl)pyrrolothiazole (2d).Reduction of 2 with lithium aluminum hydride gave the diols 3a, 3b, 3c, and 3d.These diols yielded the corresponding diacetates 4 by treatment with acetic anhydride.The bis(methylcarbamates) 5a, 5b, 5c, and 5d and bis(isopropylcarbamates) 6b and 6c are obtained with the appropiate isocyanates.The 1-substituted pyrrolizines were synthesized, the 1-acetoxy compounds 7b and 7c further transformed into 1-hydroxy (8b, 8c) and 1-oxo (9b, 9c) analogues.The action of hydrochloric acid on 1-acetoxy derivatives (7b, 7c) gave 3H-pyrrolizines (10b, 10c).Evaluation of antileukemic activity was investigated on the leukemia L1210 in vivo, on several bis(alkylcarbamates).The compounds 5c and 5d show good antileukemic activity comparable with the mitomycin.