117924-33-1 Usage
Description
Di-tert-butyl N,N-diethylphosphoramidite is a clear, colorless liquid that serves as a valuable reagent in the field of organic chemistry, particularly for the phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters.
Uses
Used in Pharmaceutical Industry:
Di-tert-butyl N,N-diethylphosphoramidite is used as a phosphitylating agent for the synthesis of water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives. These derivatives are a2a-selective adenosine receptor antagonists, which have potential applications in the treatment of various diseases and conditions.
Used in Organic Chemistry:
Di-tert-butyl N,N-diethylphosphoramidite is used as a reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. This conversion is essential in the synthesis of various organic compounds and has significant implications in the development of new drugs and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 117924-33-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,9,2 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 117924-33:
(8*1)+(7*1)+(6*7)+(5*9)+(4*2)+(3*4)+(2*3)+(1*3)=131
131 % 10 = 1
So 117924-33-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H28NO2P/c1-9-13(10-2)16(14-11(3,4)5)15-12(6,7)8/h9-10H2,1-8H3
117924-33-1Relevant articles and documents
The study of phosphoramidite as O-phosphitylation agent and its reactivity
Chen, Shui-Bing,Li, Yan-Mei,Luo, Shi-Zhong,Zhao, Gang,Tan, Bo,Zhao, Yu-Fen
, p. 277 - 291 (2000)
O-phosphorylated peptide and amino acid are important in living system. In this paper, Dialkyl-N,N-dialkyl phosphoramidites (DDPA) 3 were synthesized using two methods. The reaction of DDPA with the hydroxyl group of the corresponding amino acids in the presence of tetrazole, followed by oxidation, gave O-phosphoryl amino acid methyl esters in a good yield. A systematical study of the reactivity of DDPA was presented too.
Synthesis of Casein-Related Peptides and Phosphopeptides. VII. The efficient Synthesis of Ser(P)-Containing peptides by the Use of Boc-Ser(PO3R2)-OH Derivatives
Perich, John W.,Alewood, Paul F.,Johns, R. B.
, p. 233 - 252 (2007/10/02)
A new approach to the synthesis of Ser(PO3R2)-containing peptides by using five protected Boc-Ser(PO3R2)-OH (R = phenyl, ethyl, methyl, benzyl, t-butyl) derivatives is described.The five Boc-protected derivatives are prepared by a simple three-step synthe
REACTION OF tert-BUTYL(TETRAETHYLDIAMIDO)PHOSPHITE
Gazizov, T. Kh.,Sal'keeva, L. K.
, p. 299 - 302 (2007/10/02)
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