1182005-25-9 Usage
Description
5a-Cholest-7-en-3-ol-1,2,5a,6a-d4 is an isotopically labeled research compound, specifically a derivative of cholesterol with deuterium atoms incorporated at the 1, 2, 5, and 6 positions. 5a-Cholest-7-en-3-ol-1,2,5a,6a-d4 is utilized in various scientific research applications due to its unique isotopic labeling, which allows for enhanced tracking and analysis in biological systems.
Uses
Used in Research Applications:
5a-Cholest-7-en-3-ol-1,2,5a,6a-d4 is used as a research compound for studying the metabolism, synthesis, and transport of cholesterol and related compounds in biological systems. The isotopic labeling provides a means to differentiate this compound from its non-labeled counterparts, facilitating the investigation of its specific interactions and effects within cells and organisms.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5a-Cholest-7-en-3-ol-1,2,5a,6a-d4 is used as a labeled reference material for the development and validation of analytical methods and techniques. Its unique isotopic signature allows for the accurate measurement of its concentration and distribution in biological samples, which is crucial for the development of new drugs targeting cholesterol-related pathways.
Used in Biomedical Research:
5a-Cholest-7-en-3-ol-1,2,5a,6a-d4 is employed as a valuable tool in biomedical research, particularly in the study of cholesterol-related diseases such as atherosclerosis, Alzheimer's disease, and certain cancers. The compound's isotopic labeling enables researchers to better understand the role of cholesterol in these conditions and to develop targeted therapies that modulate cholesterol metabolism.
Used in Diagnostic Applications:
In the field of diagnostics, 5a-Cholest-7-en-3-ol-1,2,5a,6a-d4 can be used as a labeled tracer in the development of tests for monitoring cholesterol levels and related metabolic disorders. The compound's unique isotopic signature allows for the sensitive and specific detection of cholesterol and its metabolites in biological samples, aiding in the early diagnosis and management of cholesterol-related health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 1182005-25-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,2,0,0 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1182005-25:
(9*1)+(8*1)+(7*8)+(6*2)+(5*0)+(4*0)+(3*5)+(2*2)+(1*5)=109
109 % 10 = 9
So 1182005-25-9 is a valid CAS Registry Number.
1182005-25-9Relevant articles and documents
SYNTHESIS OF HIGH SPECIFIC ACTIVITY -7-DEHYDROCHOLESTEROL. CONVERSION TO ECDYSONE IN FOLLICLE CELLS OF LOCUSTA (INSECTS)
Dolle, Frederic,Kappler, Christine,Hetru, Charles,Rousseau, Bernard,Coppo, Michele,et al.
, p. 5305 - 5316 (2007/10/02)
In previous studies we have characterized the last steps of the biosynthetic pathway of the insect moulting hormone ecdysone.We are now extending our studies to the early steps and have postulated that 7-dehydrocholesterol is one of the earliest precursor molecules.To probe this hypothesis we have synthesized this molecule under tritiated form with high specific activity (2 TBq/mmol).We have devised an original pathway which includes, as a last step, the tritiation at positions 1α and 2α.In a first series of investigations, we have demonstrated that injected 7-dehydrocholesterol was efficiently converted in vivo by the ovaries of adult females of Locusta migratoria into conjugated ecdysone and 2-deoxyecdysone.In vitro incubations of 7-dehydrocholesterol with a 1.000g supernatant of a follicle cell homogenate have occasionaly yielded conversion rates into ecdysone which were as high as 10percent.
