1184086-20-1

Basic information

• Product Name: 4-methoxy-3-(2,2,2-trifluoroacetamido)benzenesulfonyl chloride
• Synonyms: 4-methoxy-3-(2,2,2-trifluoroacetamido)benzenesulfonyl chloride
• CAS NO: 1184086-20-1
• Molecular Weight: 317.673
• Mol File: 1184086-20-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-methoxy-3-(2,2,2-trifluoroacetamido)benzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-3-(2,2,2-trifluoroacetamido)benzenesulfonyl chloride(1184086-20-1)
• EPA Substance Registry System: 4-methoxy-3-(2,2,2-trifluoroacetamido)benzenesulfonyl chloride(1184086-20-1)

Safety Data

• Hazardous Substances Data: 1184086-20-1(Hazardous Substances Data)

Upstream product

• 14815-12-4 N-(2-methoxyphenyl)-2,2,2-trifluoro-acetamide 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 1335406-99-9 N-[5-(5-bromo-2-methoxybenzenesulfonyl)-2-methoxyphenyl]-2,2,2-trifluoroacetamide 
• 1335407-01-6 5-(5-bromo-2-methoxybenzenesulfonyl)-2-methoxyaniline 
• 1335407-03-8 N-[5-(5-bromo-2-methoxybenzenesulfonyl)-2-methoxyphenyl]-N-(1-methylpiperidin-4-yl)amine 
• 1335405-10-1 N-[5-(5-bromo-2-methoxybenzenesulfonyl)-2-methoxyphenyl]-N-(1-methylpiperidin-4-yl)amine hydrochloride 
• 1401621-91-7 5-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)-2-methoxyaniline 
• 1041588-69-5 N-benzyl-3-amino-4-methoxy benzene sulfonamide 
• 3889-23-4 4-((3-amino-4-methoxyphenyl)sulfonyl)thiomorpholine 1,1-dioxide 
• 56807-17-1 2-methoxy-5-(morpholin-4-ylsulfonyl)aniline 
• 99969-26-3 3-amino-4-methoxybenzenesulphonic acid methylamide 

Relevant articles and documents

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode

With the growing worldwide prevalence of antibiotic-resistant strains of tuberculosis (TB), new targets are urgently required for the development of treatments with novel modes of action. Fumarate hydratase (fumarase), a vulnerable component of the citric acid cycle in Mycobacterium tuberculosis (Mtb), is a metabolic target that could satisfy this unmet demand. A key challenge in the targeting of Mtb fumarase is its similarity to the human homolog, which shares an identical active site. A potential solution to this selectivity problem was previously found in a high-throughput screening hit that binds in a nonconserved allosteric site. In this work, a structure-activity relationship study was carried out with the determination of further structural biology on the lead series, affording derivatives with sub-micromolar inhibition. Further, the screening of this series against Mtb in vitro identified compounds with potent minimum inhibitory concentrations.

SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS

The present invention relates to novel sulfone compounds as 5-HT6 receptor ligands of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable