118409-59-9

Basic information

• Product Name: AG 99
• Synonyms: TYRPHOSTIN A46;TYRPHOSTIN AG 99;TYRPHOSTIN B40;TYRPHOSTIN 46;AG 99;ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE;3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE
• CAS NO: 118409-59-9
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.18
• Product Categories: ALCOHOL;Protein Kinase
• Mol File: 118409-59-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 544.4 °C at 760 mmHg
• Flash Point: 283 °C
• Appearance: /
• Density: 1.482 g/cm³
• Vapor Pressure: 1.83E-12mmHg at 25°C
• Refractive Index: 1.71
• Storage Temp.: 2-8°C
• CAS DataBase Reference: AG 99(CAS DataBase Reference)
• NIST Chemistry Reference: AG 99(118409-59-9)
• EPA Substance Registry System: AG 99(118409-59-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 118409-59-9(Hazardous Substances Data)

Usage

Description

AG 99, also known as Tyrphostin AG 99, is a potent, cell-permeable, and reversible inhibitor of EGFR (Epidermal Growth Factor Receptor) and EGF (Epidermal Growth Factor)-dependent cell proliferation. It plays a significant role in various cellular processes and has potential applications in different industries due to its ability to inhibit specific cellular functions.

Uses

Used in Pharmaceutical Industry:
AG 99 is used as an inhibitor for EGFR and EGF-dependent cell proliferation to target and control the growth of cancer cells. Its ability to inhibit these receptors makes it a promising candidate for the development of anti-cancer drugs and therapies.
Used in Research and Development:
AG 99 is used as a research tool in the field of cell biology and molecular biology. It helps scientists understand the role of EGFR and EGF in cell proliferation and the underlying mechanisms involved in various diseases, including cancer.
Used in Drug Discovery and Development:
AG 99 is used as a lead compound in the development of new drugs targeting EGFR and EGF-dependent cell proliferation. Its potent inhibitory activity can be leveraged to design and synthesize novel therapeutic agents with improved efficacy and selectivity.
Used in Diagnostic Applications:
AG 99 can be employed in the development of diagnostic tools and assays to detect the presence of EGFR and EGF in biological samples. This can help in the early detection of diseases associated with the overexpression or dysregulation of these receptors.

InChI:InChI=1/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+