1184224-96-1

Basic information

• Product Name: N-benzyl-2,2-difluoroethanamine
• Synonyms: N-benzyl-2,2-difluoroethanamine
• CAS NO: 1184224-96-1
• Molecular Weight: 171.19
• Mol File: 1184224-96-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl-2,2-difluoroethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2,2-difluoroethanamine(1184224-96-1)
• EPA Substance Registry System: N-benzyl-2,2-difluoroethanamine(1184224-96-1)

Safety Data

• Hazardous Substances Data: 1184224-96-1(Hazardous Substances Data)

Upstream product

• 338-65-8 1-chloro-2,2-difluoroethane 
• 100-46-9 benzylamine 

Downstream Products

• 430-67-1 2,2-difluorethylamine 
• 14321-27-8 N-ethylbenzylamine 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE STARTING FROM A BENZYLAMINE COMPOUND

Process for the preparation of 2,2-difluoroethylamine of the formula (I) [in-line-formulae]CHF2CH2NH2??(I)[/in-line-formulae] comprising the stages (i) and (ii): stage (i): reaction of 2,2-difluoro-1-haloethane of the general formula (II) [in-line-formulae]CHF2—CH2Hal??(II),[/in-line-formulae]with a benzylamine compound of the formula (III) in the presence of an acid scavenger, in which, in formula (II), Hal is chlorine, bromine or iodine, and, in the formulae (III), R1 is hydrogen or C1-C12-alkyl, and R2 is hydrogen, halogen, C1-C12-alkyl or C1-C6-alkoxy; stage (ii): catalytic hydrogenation of the N-benzyl-2,2-difluoroethanamine compound obtained in the stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.