1185514-83-3 Usage
Description
(E/Z)-N-(2-[(5-[bis(2H3methyl)amino]methylfuran-2-yl)-methyl]thioethyl)-N'-methyl-2-[15N]nitroethene-1,1-diamine is a complex organic compound with potential applications in various fields due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
(E/Z)-N-(2-[(5-[bis(2H3methyl)amino]methylfuran-2-yl)-methyl]thioethyl)-N'-methyl-2-[15N]nitroethene-1,1-diamine is used as a potential therapeutic agent for various medical conditions due to its unique chemical structure and properties.
Used in Research and Development:
(E/Z)-N-(2-[(5-[bis(2H3methyl)amino]methylfuran-2-yl)-methyl]thioethyl)-N'-methyl-2-[15N]nitroethene-1,1-diamine is used as a research compound for studying its chemical properties, interactions with biological systems, and potential applications in drug development.
Used in Analytical Chemistry:
(E/Z)-N-(2-[(5-[bis(2H3methyl)amino]methylfuran-2-yl)-methyl]thioethyl)-N'-methyl-2-[15N]nitroethene-1,1-diamine can be used as an internal standard or reference compound in various analytical techniques, such as mass spectrometry, to improve the accuracy and precision of measurements.
Check Digit Verification of cas no
The CAS Registry Mumber 1185514-83-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,5,1 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1185514-83:
(9*1)+(8*1)+(7*8)+(6*5)+(5*5)+(4*1)+(3*4)+(2*8)+(1*3)=163
163 % 10 = 3
So 1185514-83-3 is a valid CAS Registry Number.
1185514-83-3Relevant articles and documents
Ranitidine - Investigations into the Root Cause for the Presence of N-Nitroso- N, N-dimethylamine in Ranitidine Hydrochloride Drug Substances and Associated Drug Products
King, Fiona J.,Searle, Andrew D.,Urquhart, Michael W.
, p. 2915 - 2926 (2020/12/22)
The presence of low levels of N-nitroso-N,N-dimethylamine (NDMA) in ranitidine hydrochloride drug products has been reported by regulatory agencies. GlaxoSmithKline undertook a root cause analysis to investigate this observation using contemporaneous, highly sensitive analytical methodologies. The root cause analysis suggested that the presence of NDMA results from a slow degradation of the ranitidine molecule. Analysis using suitably isotopically labeled ranitidine hydrochloride confirmed the formation of NDMA solely from an intermolecular reaction of ranitidine hydrochloride without involvement of impurities. Factors that influence the rate of degradation include heat, humidity, and the crystal morphology of ranitidine hydrochloride with the material exhibiting a columnar habit showing a slower rate of degradation.
