1186195-60-7 Usage
Description
MTEP, also known as 3-[(phenylmethyl)sulfonyl]-6-(trifluoromethyl)pyridine, is a potent negative allosteric modulator of the mGlu5a receptor subtype, a type of metabotropic glutamate receptor. It has a high affinity for the mGlu5a receptor (Ki = 42 nM; IC50 = 110 nM) and is involved in the regulation of glutamate transmission in the brain.
Uses
Used in Pharmaceutical Industry:
MTEP is used as a research tool for studying the role of mGlu5 receptors in various neurological and psychiatric disorders. It helps in understanding the potential therapeutic effects of mGlu5 receptor modulation.
Used in Neurological Disorders:
MTEP is used as a potential treatment for epilepsy, ischemia, and other neurological conditions characterized by excessive mGluR transmission. By modulating the activity of mGlu5 receptors, it can help in reducing the severity and frequency of these disorders.
Used in Psychiatric Disorders:
MTEP is used as a potential treatment for anxiety and depression. It has demonstrated anxiolytic-like effects in rodent models, similar to benzodiazepines, without causing sedation or addiction. Additionally, it has shown antidepressant effects in several rodent models of depression.
Used in Neuroprotection:
MTEP is used for its neuroprotective potential, as it can prevent excitotoxic neuronal damage when administered through intrahippocampal or intraperitoneal injection. This property makes it a promising candidate for the treatment of neurodegenerative diseases and conditions involving neuronal damage.
in vitro
like mpep, mtep showed a nanomolar affinity for mglur5, but seemed to be superior to mpep in term of specificity. mtep did not influence mglur2, mglur7, nmda, ampa or kainate receptors, while inhibited maoa at a concentration three times higher than mpep. moreover, recent study indicated that mtep was five times stronger that mpep as an anxiolytic compound [1].
in vivo
mtep with doses between 0.5 and 3 mg/kg was found to decrease the haloperidol-induced muscle rigidity, which was measured as an increased muscle resistance of the rat hind leg. the longest and strongest effect was observed with the dose of 1 mg/kg. mtep was also found to reduce the haloperidol-induced increase in electromyographic activity recorded in the tibialis anterior and gastrocnemius muscles. 3 and 5 mg/kg of mtep could inhibit the haloperidol- induced catalepsy [1].
IC 50
5 nm
references
[1] ossowska k,konieczny j,wolfarth s,pilc a. mtep, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mglur5), produces antiparkinsonian-like effects in rats. neuropharmacology.2005 sep;49(4):447-55.
Check Digit Verification of cas no
The CAS Registry Mumber 1186195-60-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,6,1,9 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1186195-60:
(9*1)+(8*1)+(7*8)+(6*6)+(5*1)+(4*9)+(3*5)+(2*6)+(1*0)=177
177 % 10 = 7
So 1186195-60-7 is a valid CAS Registry Number.
